Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K Channel K1.2 and Small- and Intermediate-Conductance Ca-Activated K Channels K2.2 and K3.1.

A novel peptide, Cm39, was identified in the venom of the scorpion . Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.

Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors.

Unlabelled: Centruroides margaritatus scorpion stings are common in Colombia. However, the cardiovascular toxicity of the venom has not been clarified.

Aim: To study the effect and mechanisms of action of the complete venom of C.