Effectiveness and Safety of 4-factor Prothrombin Complex Concentrate (4PCC) in Neonates With Intractable Bleeding or Severe Coagulation Disturbances: A Retrospective Study of 37 Cases.

Background: To date, clinical experience with prothrombin complex concentrate (PCC) in the neonatal population has been limited.

Aim: The objective of this study was to describe our experience regarding the effectiveness and safety of PCC administration in newborns with severe bleeding or coagulopathy resistant to conventional therapy.

Methodology: We retrospectively analyzed data from 37 neonates with intractable bleeding or severe coagulation disturbances.