Publications by authors named "Margarita Eisenberg"
Bioorg Med Chem
June 2013
Article Synopsis
- Repeat proteins play a crucial role in molecular recognition across various cellular systems and may serve as alternatives to antibodies.
- The research outlines a new method for creating and screening small libraries of repeat proteins, specifically a three-repeat tetratricopeptide (TPR) protein, although initial synthesis efforts proved challenging for proteins with varying repeat numbers.
- The study introduces dynamic combinatorial libraries (DCLs), which can generate TPR proteins with up to eight repeats, enhancing their binding capabilities with ligands, thus offering a rapid approach for screening proteins with diverse binding surfaces.
