Publications by authors named "Margarita Beltran Garcia"
Antibiotic use and outcome in patients with negative blood cultures, a new target population for antimicrobial stewardship interventions: A prospective multicentre cohort (NO-BACT).
J Infect
February 2024
Objectives: To evaluate the appropriateness of antimicrobial treatment and the risk factors for mortality in patients with negative blood cultures (BC), in order to evaluate whether this population would be a suitable target for antimicrobial stewardship (AMS) interventions.
Methods: A multicentre prospective cohort study of patients with negative BC in three Spanish hospitals between October 2018 and July 2019 was performed. The main endpoints were the appropriateness of antimicrobial treatment (evaluated by two investigators according to local guidelines) and 30-day mortality.
Antibiotic stewardship programs (ASP) have already demonstrated clinical benefits. We aimed to describe the Point Prevalence Surveys (PPS) methodology implemented in our hospital as an efficient tool to guide ASP strategies. Annually repeated PPS were conducted from 2012 to 2019 at a 750-bed university hospital in South Spain.
View Article and Find Full Text PDFEfficacy of diet on fatigue, quality of life and disability status in multiple sclerosis patients: rapid review and meta-analysis of randomized controlled trials.
BMC Neurol
October 2022
Article Synopsis
- Multiple sclerosis (MS) is a chronic condition that causes fatigue and impacts quality of life, leading many patients to explore different diets in search of relief due to a lack of specific dietary guidance.
- A rapid review and meta-analysis of randomized controlled trials (RCTs) was conducted, focusing on the effects of dietary interventions on fatigue, quality of life (QOL), disability status, and adverse events in MS patients.
- The analysis of eight studies involving 515 patients indicated that dietary interventions are linked to a reduction in fatigue and an improvement in QOL, with no significant impact on disability status and no severe adverse effects reported.
Background: There is lack of information on the efficacy and safety of piperacillin–tazobactam administered by continuous infusion.
Objective: The aim of this study was to investigate whether continuous infusion of piperacillin–tazobactam is superior in terms of efficacy to a 30 % higher dose administered by intermittent infusion to treat suspected or confirmed infection due to Pseudomonas aeruginosa. Setting Multicenter clinical trial with 11 third level Spanish hospitals.