Publications by authors named "Margarita A Shpilyuk"
Article Synopsis
- Umbilical cord blood's use in hemostasis testing for newborns is under-researched, leading to this study aimed at evaluating its applicability compared to venous blood samples.
- The study involved 187 newborns and found that umbilical cord blood exhibited a hypocoagulable shift in clotting times and fibrinogen levels, while thromboelastometry and thrombodynamics showed a hypercoagulable shift in newborn blood.
- The differences in hemostatic parameters highlight that newborns have distinct coagulation profiles compared to adults, with implications for understanding their physiological and pathological hemostatic features.
Mesenchymal stem cells (MSCs) have emerged as a potent therapeutic tool for the treatment of a number of pathologies, including immune pathologies. However, unwelcome effects of MSCs on blood coagulation have been reported, motivating us to explore the thrombotic properties of human MSCs from the umbilical cord. We revealed strong procoagulant effects of MSCs on human blood and platelet-free plasma using rotational thromboelastometry and thrombodynamic tests.
View Article and Find Full Text PDFIntroduction: The incidence of venous thromboembolism (VTE) after cesarean section is up to 0.6%, and the widespread use of cesarean section draws attention to this group. The dosage and duration of low-molecular-weight heparin (LMWH) prophylaxis after delivery is estimated by anamnestic risk-scales; however, the predictive potency for an individual patient's risk can be low.
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