Randomized double-blind study on safety and tolerability of TP-102 phage cocktail in patients with infected and non-infected diabetic foot ulcers.

Background: Phage therapy offers a promising alternative for treating serious infections, including diabetic foot ulcers (DFUs), through the lytic action of phages. This randomized double-blind study was conducted to evaluate the safety and tolerability of the TP-102 bacteriophage cocktail in patients with DFUs non-infected and infected with Staphylococcus aureus, Pseudomonas aeruginosa, and/or Acinetobacter baumannii.

Methods: Nineteen participants with DFUs were randomized after susceptibility testing.

The Link Between Major Life Events and Quality of Life: The Role of Compassionate Abilities.

This study examined whether compassionate skills (the ability to be self-compassionate and to receive compassion from others) operate as mediator processes in the relationship between negative major life events and psychological quality of life (QoL), in 467 adults. The path model accounted for 48% of psychological QoL' variance and indicated that negative appraisal of major life events was associated with decreased psychological QoL, through increased levels of shame and less compassionate abilities. Findings support the importance of community programmes to enhance psychological QoL, that help individuals cultivate self-compassion and the ability to receive compassion from others, especially in face of adverse events.

Development of Gel-in-Oil Emulsions for Khellin Topical Delivery.

Hypopigmentation is a progressive dermatological condition caused by a reduction in the skin pigment, melanin. Its treatment is considered a challenge due to the lack of a highly efficient single therapy. Currently, the main treatments include photochemotherapy, application of corticosteroids and immunosuppressants, and laser.