Publications by authors named "Margareta Kurkela"
Article Synopsis
- Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enzyme linked to severe neurological issues such as HIDEA syndrome, characterized by conditions like hypotonia and intellectual disability.
- Research on P4h-tm mice revealed significant changes in their energy and glucose metabolism, including altered physical activity and muscle weakness compared to wild-type mice.
- While the exact causes of these changes are not fully understood, the altered physiology in P4h-tm mice mirrors symptoms seen in HIDEA patients, indicating this model could help develop targeted therapies.
Alzheimer's disease (AD) is the most common cause of dementia with limited treatment options affecting millions of people and the prevalence increasing with the aging population. The current knowledge on the role of the hypoxia/hypoxia-inducible factor (HIF) in the AD pathology is restricted and controversial. We hypothesized based on benefits of the genetic long-term inactivation of HIF prolyl 4-hydroxylase-2 (HIF-P4H-2) on metabolism, vasculature and inflammatory response that prolonged moderate activation of the hypoxia response could hinder AD pathology.
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