Publications by authors named "Margaret Zielinski"
Article Synopsis
- The study investigated the use of transcranial focused ultrasound (tfUS) to treat patients with treatment-refractory generalized anxiety disorder (trGAD) by targeting the right amygdala.
- Twenty-five participants received eight weekly tfUS sessions and were assessed using anxiety measures such as the Hamilton Anxiety Inventory (HAM-A) and Beck Anxiety Inventory (BAI), showing significant reductions in anxiety levels post-treatment.
- The findings indicate that tfUS is a safe and potentially effective intervention for anxiety disorders, meriting further research into its applications for psychiatric and neurological conditions.
Background: Alzheimer's disease (AD) is a progressive, multifactorial, neurodegenerative disorder affecting >6 million Americans. Chronic, low-grade neuroinflammation, and insulin resistance may drive AD pathogenesis. We explored the neurophysiological and neuropsychological effects of NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, in AD.
View Article and Find Full Text PDFThis study intended to evaluate the safety and possible therapeutic effect of transcranial infrared laser stimulation (TILS) based on photobiomodulation (PBM) among patients with traumatic brain injury (TBI). Eleven participants who were diagnosed with TBI after full neurological examination and MRI evaluation by a board-certified neurologist completed five to eight 20-minute TILS sessions using the Cytonsys CytonPro-5000 apparatus (pilot laser control, focused wavelength of 1064 nm, maximum output power of 10W, maximum optical power density of 500 mW/cm, effective area 4.5 cm in diameter).
View Article and Find Full Text PDFPlasmalogens are a specific type of glycerophospholipid found in especially high levels in neuronal membranes. Decreased blood and brain levels of docosahexaenoic acid (DHA) containing plasmalogens are associated with decreased cognition and neuromuscular function in humans. Administration of 1-O-alkyl-2-acylglycerol (AAG) plasmalogen precursors containing DHA at the sn-2 position dose-dependently increase blood DHA plasmalogens and are neuroprotective in animal models of neurodegeneration at doses between 10 and 50 mg/kg.
View Article and Find Full Text PDFIn the past, psychotherapy and neuropharmacological approaches have been the most common treatments for disordered thoughts, moods, and behaviors. One new path of brain therapeutics is in the deployment of noninvasive approaches designed to reprogram brain function at the cellular level. Treatment at the cellular level may be considered for a wide array of disorders, ranging from mood disorders to neurodegenerative disorders.
View Article and Find Full Text PDFBackground: Interventions for chronic discogenic spine pain are currently insufficient in lowering individual patient suffering and global disease burden. A 2016 study of platelet rich plasma (PRP) for chronic discogenic pain previously demonstrated clinically significant response among active group patients compared with controls.
Objectives: To replicate the previous research to move this intervention forward as a viable option for patient care.