Acute sleep deprivation disrupts emotion, cognition, inflammation, and cortisol in young healthy adults.

Chronic sleep deprivation has been demonstrated to diminish cognitive performance, alter mood states, and concomitantly dysregulate inflammation and stress hormones. At present, however, there is little understanding of how an acute sleep deprivation may collectively affect these factors and alter functioning. The present study aimed to determine the extent to which 24-h of sleep deprivation influences inflammatory cytokines, stress hormones, cognitive processing across domains, and emotion states.

Catechol-O-methyltransferase Val158Met polymorphism associates with affect and cortisol levels in women.

Introduction: We tested the extent to which the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with affective state and evening cortisol levels. We limited our study to women as previous research suggests that the link between COMT genotype and psychological health is entangled by sex differences.

Materials And Methods: The participants were assessed on measures of anxiety, mood disturbance, depressive symptomatology, and perceived stress.