Publications by authors named "Margaret Runner"
Article Synopsis
- The study aimed to assess the effectiveness of a modified intravitreal methotrexate (MTX) treatment to prevent proliferative vitreoretinopathy (PVR) after silicone oil removal in patients who had retinal detachment repair.
- Involved 52 eyes from 52 patients, split into two treatment groups and a control group, with the main outcomes being retinal attachment rates and visual acuity over a follow-up period of at least 6 months post-silicone oil removal.
- Results showed that while retinal attachment rates were similar across groups, Group 1 had significantly lower rates of complications like epiretinal membrane and cystoid macular edema compared to Group 2 and control, suggesting that post-operative MTX injections
: Gene therapy's emergence has made molecular diagnosis for inherited retinal diseases clinically significant. Free genetic testing panels have improved testing access in clinical practice, yet the interpretation of results, especially variants of unknown significance (VUS), remains challenging and requires expertise. This study shares our experience in utilizing sponsored IRD panel tests by Invitae and Blueprint Genetics (BG), reporting their positivity rates, and comparing their reclassification of variants through amendments.
View Article and Find Full Text PDFPurpose: Although pivotal trials have demonstrated efficacy of anti-vascular endothelial growth factor therapy in neovascular age-related macular degeneration, there is a paucity of clinical data about the long-term (>5 years) treatment.
Methods: Retrospective analysis of all patients with neovascular age-related macular degeneration who were actively treated, had received >40 anti-vascular endothelial growth factor injections, and were followed for ≥5 years. Snellen-corrected visual acuity, initial drug choice, and times elapsed between treatments were collected.
Purpose: To report on macular hole repair in macular telangiectasia type 2 (MacTel2).
Design: Global, multicenter, retrospective case series.
Participants: Patients undergoing surgery for MacTel2-associated full-thickness macular hole (MTMH).
Background: Here, we present a semi-automated method for quantifying retinal ganglion cell (RGC) axon density at different distances from the optic nerve crush site using longitudinal, confocal microscopy images taken from whole-mounted optic nerves. This method employs the algorithm AxonQuantifier which operates on the freely available program, ImageJ.
New Method: To validate this method, seven adult male Long Evans rats underwent optic nerve crush injury followed by in vivo treatment with electric fields of varying strengths for 30 days to produce optic nerves with a wide range of axon densities distal to the optic nerve crush site.