Genomic and Untargeted Metabolomic Analysis of Secondary Metabolites in the Strain MH191 Shows Media-Based Dependency for the Production of Bioactive Compounds with Potential Antifungal Activity.

species can form beneficial relationships with hosts as endophytes, including the phytopathogen-inhibiting strain, MH191, isolated from wheat plants. Using genomic characterization and untargeted metabolomics, we explored the capacity of strain MH191 to inhibit a range of fungal phytopathogens through the production of secondary metabolites. Complete genome assembly of strain MH191 predicted 24 biosynthetic gene clusters.

and their specialised metabolites for phytopathogen control - comparative and metabolic approaches.

In the search for new crop protection microbial biocontrol agents, isolates from the genus are commonly found with promising attributes. are natural soil dwellers and have evolved as plant symbionts producing specialised metabolites with antibiotic and antifungal activities. biocontrol strains can effectively suppress plant pathogens via direct antimicrobial activity, but also induce plant resistance through indirect biosynthetic pathways.