Alcohol-related cognitive impairments in patients with and without cirrhosis.

Aims: up to 80% of patients with alcohol use disorder display cognitive impairments. Some studies have suggested that alcohol-related cognitive impairments could be worsened by hepatic damage. The primary objective of this study was to compare mean scores on the Brief Evaluation of Alcohol-Related Neurocognitive Impairments measure between alcohol use disorder patients with (CIR+) or without cirrhosis (CIR-).

Alcohol demand in college students: The roles of athletic involvement and gender.

College student-athletes represent a high-risk group for heavy alcohol consumption and negative alcohol-related consequences. Although college drinking correlates with access to low-cost alcohol, no study has examined demand, or the relationship between price and consumption, in student-athletes. Furthermore, the prevalence of anxiety, depression, and drinking to cope motives in student-athletes suggest athlete-specific risks of alcohol consumption that have not yet been examined in conjunction with demand.

A new statistical model for binge drinking pattern classification in college-student populations.

Background: Binge drinking (BD) among students is a frequent alcohol consumption pattern that produces adverse consequences. A widely discussed difficulty in the scientific community is defining and characterizing BD patterns. This study aimed to find homogenous drinking groups and then provide a new tool, based on a model that includes several key factors of BD, to assess the severity of BD regardless of the individual's gender.

Changes in Alcohol Consumption among Users of an Internet Drug Forum during a COVID-19 Lockdown.

Background: The aim of the present study was to assess the frequency and clinical correlates of users of an Internet drug forum who changed their alcohol use during the March-May 2020 COVID-19 lockdown in France.

Methods: An anonymous Internet-based cross-sectional survey during the COVID-19 lockdown was used via messages on a French Internet drug forum. Participants reported any increase in their alcohol consumption during the lockdown.

Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder.

Aims: To assess recovery of alcohol-related neuropsychological deficits in a group of patients with pure severe alcohol use disorder (AUD) during a detoxification program using the Brief Evaluation of Alcohol-Related Neuropsychological Impairment (BEARNI) test.

Methods: Thirty-two patients with severe AUD using DSM-IV criteria (24 men, mean age = 45.5 ± 6.

The behavioral economics of alcohol demand in Greek-affiliated college students.

Background: College students affiliated with fraternity and sorority, or "Greek" life represent a known high-risk group for alcohol consumption and related consequences, but little is known about demand for alcohol in this population. The current study examined behavioral economic demand for alcohol in a sample of Greek life-affiliated undergraduate students using the alcohol purchase task (APT) and a novel variation of the APT that included a fixed-price, nonalcoholic alternative (APT Choice).

Methods: Participants (n = 229) completed the APT, APT Choice, Alcohol Use Disorders Identification Test (AUDIT), and Daily Drinking Questionnaire (DDQ).

Patch-Clamp Recording of Low Frequency Stimulation-induced Long-Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Neurodevelopment.

Background: Studying synaptic plasticity in the rat hippocampus slice is a well-established way to analyze cellular mechanisms related to learning and memory. Different modes of recording can be used, such as extracellular field excitatory post-synaptic potential (EPSP) and diverse patch-clamp methods. However, most studies using these methods have examined only up to the juvenile stage of brain maturation, which is known to terminate during late adolescence/early adulthood.

The behavioral economics of the bottomless cup: The effects of alcohol cup price on consumption in college students.

Heavy drinking among college students is a public health concern in part due to the accessibility of alcohol and promotions such as "happy hours," which discount the price of alcohol. In addition, consuming alcohol at unregulated off-campus parties may result in greater alcohol consumption, higher blood alcohol concentrations, and increased negative consequences. The purpose of the current study was to assess demand for a refillable red "Solo" cup using a new hypothetical purchase task, the Cup-Price Purchase Task (CPPT).

Predicting adverse consequences of alcohol consumption in underage college students using a novel Fake ID Purchase Task.

Underage drinking is a significant public health concern, specifically among college students. The availability of fake IDs increases risks of college binge drinking as well as sexual victimization, providing a call for research on behavioral correlates. The purpose of the present experiment was to determine how much money an underage college sample ( = 98) at a large Midwestern university would be willing to pay to obtain a fake ID and to identify relations between demand for alcoholic drinks, demand for a fake ID, and adverse consequences of past alcohol consumption as measured by the Brief Young Adult Alcohol Consequences Questionnaire.

The Behavioral Economics of Alcohol Demand in French and American University Students.

Background: Behavioral economic approaches have revealed several characteristics of alcohol demand (e.g., intensity, elasticity, and essential value) in university students; however, these approaches have not yet examined alcohol demand among students outside of the United States.

Ethanol (EtOH)-Related Behaviors in α-Synuclein Mutant Mice and Association of SNCA SNPs with Anxiety in EtOH-Dependent Patients.

Background: Data have shown a role of α-synuclein in anxiety and also in addiction, particularly in alcohol use disorders (AUD). Since the comorbidity between AUD and anxiety is very high and because anxiety is an important factor in ethanol (EtOH) relapse, the aim of the present study was to investigate the role of α-synuclein in moderating EtOH intake, the anxiolytic effects of EtOH, and EtOH withdrawal-induced anxiety and convulsions in mice. The study aimed to determine whether SNCA variants moderated anxiety in EtOH-dependent patients.

Animal models of binge drinking, current challenges to improve face validity.

Binge drinking (BD), i.e., consuming a large amount of alcohol in a short period of time, is an increasing public health issue.

The effects of next-day class characteristics on alcohol demand in college students.

Behavioral economic principles have been useful for addressing strategies to reduce alcohol consumption among college students. For example, academic variables (such as class schedule or academic rigor) have been found to affect alcohol demand assessed with a hypothetical alcohol purchase task (APT). The present studies used the APT to address the effects of 2 academic variables: next-day course level (no class, introductory level or upper level) and class size (no class, 30-student or 12-student).

Delay discounting for sucrose in alcohol-preferring and nonpreferring rats using a sipper tube within-sessions task.

Background: Delay discounting (DD) is a measure of impulsivity that quantifies preference for a small reward delivered immediately over a large reward delivered after a delay. It has been hypothesized that impulsivity is an endophenotype associated with increased risk for development of alcohol use disorders (AUDs); however, a causal role of impulsivity is difficult to determine with human studies. We tested this hypothesis by assessing the degree of DD present in alcohol-naïve rats selectively bred for either high- or low-alcohol preference.

Academic constraints on alcohol consumption in college students: a behavioral economic analysis.

Behavioral economic analyses recently have been extended to alcohol drinking among college students. The current study used a hypothetical alcohol purchase task (APT) to assess the effects of academic constraints (next-day class time and next-day class requirement) on alcohol demand among college students. Participants were asked to read a description of a drinking scenario and indicate how many standard drinks they would consume at a variety of prices.

Matching law choice analyses of ethanol and sucrose consumption in alcohol-preferring (P), nonpreferring (NP), and Sprague-Dawley (SD) rats.

Background: Quantitative models of choice, such as the matching law and behavioral economics, allow for the analysis of alcohol consumption within a choice context. Such models can provide further knowledge of phenotypic differences between selected lines of rats. The current study applied the generalized matching law to the ethanol (EtOH) and sucrose consumption of alcohol-preferring (P), nonpreferring (NP), and Sprague-Dawley (SD) rats.

Limited-access consumption of ascending ethanol concentrations in alcohol-preferring, nonpreferring, and Sprague-Dawley rats.

Background: Ethanol intake and preference differences between the selectively bred alcohol-preferring (P) and nonpreferring (NP) rats have generally been studied in a continuous-access paradigm using 10% ethanol. Little is known about the consumption of lower concentrations of ethanol in these lines or consumption of a wide range of ethanol concentrations in limited-access paradigms. Recently, limited-access paradigms have been used to study the biological and pharmacological mechanisms of ethanol consumption in animal models.

Methadone and nicotine self-administration in humans: a behavioral economic analysis.

Rationale: Prior research has revealed inconsistencies in the behavioral relations between nicotine and opiates among methadone-maintained patients.

Objectives: The current study examined whether the drug reinforcers cigarette puffs and methadone were economic complements or substitutes.

Methods: Five methadone-maintained, nicotine-dependent participants were trained to self-administer methadone, cigarette puffs, or concurrently available methadone and puffs.