Publications by authors named "Margaret M Patterson"
Non-contact anterior cruciate ligament (ACL) rupture is a common serious orthopaedic disease in humans and dogs. Familial risk has been recognized in both species but interactions between genetic effects and environmental risk are not understood. We investigated ACL rupture heritability, genetic architecture, selection pressure, sharing of risk genes and biological pathways, and polygenic risk score (PRS) prediction of disease risk.
View Article and Find Full Text PDFLate-onset peripheral neuropathy (LPN) is a heritable canine neuropathy commonly found in Labrador retrievers and is characterized by laryngeal paralysis and pelvic limb paresis. Our objective was to establish canine LPN as a model for human hereditary peripheral neuropathy by classifying it as either an axonopathy or myelinopathy and evaluating length-dependent degeneration. We conducted a motor nerve conduction study of the sciatic and ulnar nerves, electromyography (EMG) of appendicular and epaxial musculature, and histologic analysis of sciatic and recurrent laryngeal nerves in LPN-affected and control dogs.
View Article and Find Full Text PDFArticle Synopsis
- Spontaneous tendon and ligament ruptures, particularly degenerative suspensory ligament desmitis (DSLD), are common in equine species, especially affecting breeds like the Peruvian Horse, suggesting a genetic link.
- A study involving 183 Peruvian Horses identified 151 risk-related genetic markers (SNPs) associated with DSLD and highlighted heritability estimates around 0.22, indicating a moderate genetic influence.
- The research discovered significant genomic regions on several chromosomes, pinpointed 66 genes with selection signatures, and indicated that pathways like proteoglycan metabolism and hedgehog signaling may play roles in DSLD risk, with strong predictive performance achieved using genomic modeling.
Objective: To determine the presentation, diagnosis, progression, and family risk of fibrotic myopathy, a disease with marked breed predisposition in the German Shepherd Dog (GSD).
Animals: 41 dogs prospectively recruited to the University of Wisconsin-Madison Comparative Genetics and Orthopedic Laboratory between November 2019 to August 2022.
Methods: Medical records of dogs diagnosed with fibrotic myopathy were reviewed upon referral.