Publications by authors named "Margaret Jeng"
Article Synopsis
- Septic shock leads to over 40% mortality, transitioning from early hyper-inflammation to hypo-inflammation, making patients vulnerable to secondary infections.
- The study examines how plasma metabolites from septic shock patients impact immune responses, focusing on cell stimulation with E. Coli lipopolysaccharide (LPS) and plasma metabolomics.
- Findings reveal that septic shock patients show endotoxin tolerance and significant accumulation of various metabolites, which can either suppress or enhance the inflammatory response of immune cells.
Objectives: Diagnosis of pneumonia is challenging in critically ill, intubated patients due to limited diagnostic modalities. Endotracheal aspirate (EA) cultures are standard of care in many ICUs; however, frequent EA contamination leads to unnecessary antibiotic use. Nonbronchoscopic bronchoalveolar lavage (NBBL) obtains sterile, alveolar cultures, avoiding contamination.
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