Publications by authors named "Margaret Hays"
Background: Invasive mechanical ventilation in critically ill adults involves adjusting the fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation target that will optimize clinical outcomes in this patient population remains unknown.
Methods: In a pragmatic, cluster-randomized, cluster-crossover trial conducted in the emergency department and medical intensive care unit at an academic center, we assigned adults who were receiving mechanical ventilation to a lower target for oxygen saturation as measured by pulse oximetry (Spo) (90%; goal range, 88 to 92%), an intermediate target (94%; goal range, 92 to 96%), or a higher target (98%; goal range, 96 to 100%).
Article Synopsis
- The PILOT trial is a study aimed at determining the best oxygen saturation levels (SpO targets) for patients on mechanical ventilation in ICU settings, comparing low, intermediate, and high SpO targets.
- Conducted at Vanderbilt University Medical Center, the trial features a unique design where participating units switch their assigned SpO targets every two months, measuring the number of days patients can breathe without a ventilator over 28 days.
- The study has received ethical approval and aims to share its findings through scientific publications and conferences.
Article Synopsis
- A randomized trial was conducted at 34 US hospitals to assess the effectiveness of hydroxychloroquine for treating hospitalized adults with COVID-19, enrolling 479 patients from April to June 2020 and stopping early due to futility.
- Participants were divided into two groups, receiving either hydroxychloroquine or a placebo, with primary outcomes measured 14 days post-randomization using a 7-category scale.
- Results showed that despite a diverse patient sample, hydroxychloroquine did not demonstrate improved clinical outcomes compared to the placebo, leading to a conclusion of its ineffectiveness for this patient population.
Objective: Enteral nutrition is provided to mechanically ventilated patients who cannot eat normally, yet the amount of support needed is unknown. We conducted this randomized, open-label study to test the hypothesis that initial low-volume (i.e.
View Article and Find Full Text PDFReported stressors and ways of coping utilized by intensive care unit nurses.
Dimens Crit Care Nurs
September 2006
Registered nurses within the intensive care unit work within a fast-paced, highly technologic setting, caring for patients with complex needs. The purpose of this investigation was to identify stressors intensive care unit nurses perceived as most prevalent within their work setting, and the types of coping utilized by nurses in this setting. The research design was a descriptive method that utilized a survey among a convenience sample of nurses, employed within the intensive care unit setting at 7 acute care metropolitan hospitals.
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