Publications by authors named "Margaret Gale-Rowe"

Article Synopsis
  • The Public Health Agency of Canada faced a challenge during the COVID-19 pandemic in managing numerous investigational therapeutics and needed an effective way to prioritize their assessment.
  • They created the Rapid Scoring Tool (RST) through a literature search and validation process, aiming to streamline the review of potential treatments based on specific criteria.
  • The RST, which utilizes a unique scoring system from -10 to 10, effectively ranks therapeutics and can adapt to evolving information, indicating its potential for broader applications in future health crises.
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For over 30 years, the Government of Canada has developed guidelines on sexually transmitted and blood-borne infections (STBBI) with a group of subject matter experts. This expert group provided advice to the Public Health Agency of Canada (PHAC) from 2004 to 2019; transitioning to the National Advisory Committee on STBBI (NAC-STBBI) in 2019. NAC-STBBI supports PHAC's mandate to prevent and control infectious diseases by providing advice for the development of STBBI guidelines.

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Objective: To establish a baseline for physicians' knowledge of and counseling practices on the use of antibiotics and antimicrobial resistance (AMR), and to determine potential changes in these measures after the implementation of a national AMR awareness campaign.

Design: Cross-sectional design.

Setting: Canada.

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Objective: To provide recommendations on the management of gonococcal infection among adults and youth.

Quality Of Evidence: Treatment recommendations in the Canadian guidelines on sexually transmitted infections are based on review of the literature, as well as the grades of recommendations and the levels of evidence quality determined by a minimum of 2 reviewers. The recommendations are peer-reviewed and require approval by the expert working group.

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Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosis (TB). Here we report evidence-based guidelines from the World Health Organization for a public health approach to the management of LTBI in high risk individuals in countries with high or middle upper income and TB incidence of <100 per 100 000 per year. The guidelines strongly recommend systematic testing and treatment of LTBI in people living with HIV, adult and child contacts of pulmonary TB cases, patients initiating anti-tumour necrosis factor treatment, patients receiving dialysis, patients preparing for organ or haematological transplantation, and patients with silicosis.

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Objective: Regular HIV testing and early detection leads to timely treatment. Appropriate treatment and care can prevent disease progression in the individual and prevent onwards transmission within the community. This review describes HIV testing coverage in populations disproportionately affected by HIV and in the general population in Canada.

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Objective: We aimed to assess the potential prevention benefits of HIV treatment as prevention (TasP) in resource-rich countries and examine the potential interactions between TasP and other prevention strategies by reviewing mathematical models of TasP.

Method: Multiple databases were searched for mathematical models published in the previous 5 years (from July 2007 to July 2012). The nine models located were set in Canada, Australia and the United States.

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