Publications by authors named "Margaret D Krasne"

Article Synopsis
  • The study aims to assess the impacts of early screening for palliative care in ICU patients to align their care with personal goals and potentially shorten their ICU stays.* -
  • Using a retrospective cohort approach, researchers compared ICU admissions before and after implementing palliative care screening, focusing on how this screening affected the use of specialist palliative care and various patient outcomes.* -
  • Results showed that after screening implementation, there was a significant increase in early palliative care consultations (17% vs 1%), indicating a positive shift in palliative care use following the new protocol.*
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Although cancer care is often contextualized in terms of survival, there are other important cancer care outcomes, such as quality of life and cost of care. The ASCO Value Framework assesses the value of cancer therapies not only in terms of survival but also with consideration of quality of life and financial cost. Early palliative care for patients with advanced cancer is associated with improved quality of life, mood, symptoms, and overall survival for patients, as well as cost savings.

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Chronic inflammation is recognized as a risk factor for the development of several malignancies. Local white adipose tissue (WAT) inflammation, defined by the presence of dead or dying adipocytes encircled by macrophages that form crown-like structures (CLS), occurs in the breasts (CLS-B) of most overweight and obese women. Previously, we showed that the presence of CLS-B is associated with elevated tissue levels of proinflammatory mediators and aromatase, the rate-limiting enzyme for estrogen biosynthesis.

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