A review found small variable blocking schemes may not protect against selection bias in randomized controlled trials.

Objective: Blocking is associated with prediction of the allocation sequence and subversion. This paper explores if blocking strategies lead to an increase in baseline age heterogeneity (a marker for potential subversion) and, whether the use of blocking is changing over time.

Study Design And Settings: The British Medical Journal, Journal of the American Medical Association, The Lancet and the New England Journal of Medicine were hand searched to identify open RCTs published in January between 2001 and 2020.

Rapid and continuous modulation of hippocampal network state during exploration of new places.

Hippocampal information processing is often described as two-state, with a place cell state during movement and a reactivation state during stillness. Relatively little is known about how the network transitions between these different patterns of activity during exploration. Here we show that hippocampal network changes quickly and continuously as animals explore and become familiar with initially novel places.

Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.

The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and memory, the specific role of awake replay remains unclear.

Transient slow gamma synchrony underlies hippocampal memory replay.

The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and across hemispheres. The mechanism of this coordination is not understood.

A single microcircuit with multiple functions: state dependent information processing in the hippocampus.

Many neural circuits process information in multiple distinct modes. For example, the hippocampus is involved in memory encoding, retrieval, and consolidation processes. These different mnemonic computations require processing of differing balances of current sensory input and previously stored associations.

Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval.

The hippocampus is required for the encoding, consolidation and retrieval of event memories. Although the neural mechanisms that underlie these processes are only partially understood, a series of recent papers point to awake memory replay as a potential contributor to both consolidation and retrieval. Replay is the sequential reactivation of hippocampal place cells that represent previously experienced behavioral trajectories and occurs frequently in the awake state, particularly during periods of relative immobility.

Experience-dependent development of coordinated hippocampal spatial activity representing the similarity of related locations.

To learn we must identify and remember experiences uniquely but also generalize across experiences to extract common features. Hippocampal place cells can show similar firing patterns across locations, but the functional significance of this repetitive activity and the role of experience and learning in generating it are not understood. We therefore examined rat hippocampal place cell activity in the context of spatial tasks with multiple similar spatial trajectories.

Placental laser surgery for severe previable feto-fetal transfusion syndrome in triplet gestation.

Information on feto-fetal transfusion syndrome (FFTS) in higher-order multifetal gestation is limited. We report outcomes of 10 triplet pregnancies treated by fetoscopic laser occlusion of the chorioangiopagous vessels (FLOC). The study period was August 1992 to August 2008.

Antenatal fetal surveillance in pregnancies complicated by fetal gastroschisis.

Objective: The purpose of this study was to determine if antenatal fetal surveillance should be considered in pregnancies complicated by fetal gastroschisis, and if so, what gestational age should testing begin.

Study Design: During an 18-year period, all pregnancies delivered of a newborn that had gastroschisis were identified. Numerous data parameters were collected, including gestational age at delivery, birthweight, indication for delivery, antenatal testing results if performed, and neonatal outcome.

The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study.

Objective: This study was undertaken to determine whether the neonatal benefit of a single complete course of antenatal corticosteroids diminishes when delivery is remote from administration (> 14 days).

Study Design: This retrospective 2 center cohort trial included women who received a single complete course of antenatal corticosteroids and delivered a viable singleton infant between 26 and 34 weeks of gestation. Patients were divided into 1 of 2 groups on the basis of the interval from first corticosteroid dose to delivery (2-14 days and > 14 days).

Anterior lingual thyroglossal cyst: antenatal diagnosis, management, and long-term outcome.

Objective: To describe the long-term outcome of a large anterior lingual thyroglossal duct cyst, diagnosed antenatally by ultrasound that completely obstructed the oral cavity and had almost completely replaced the anterior two-thirds lingual musculature.

Methods: Longitudinal observation.

Results: Anticipated airway obstruction at birth did not occur.