Partial differential systems with non-local nonlinearities: generation and solutions.

We develop a method for generating solutions to large classes of evolutionary partial differential systems with non-local nonlinearities. For arbitrary initial data, the solutions are generated from the corresponding linearized equations. The key is a Fredholm integral equation relating the linearized flow to an auxiliary linear flow.

A modular gene targeting system for sequential transgene stacking in plants.

A modular, selection-based method was developed for site-specific integration of transgenes into a genomic locus to create multigene stacks. High-frequency gene targeting was obtained using zinc finger nuclease (ZFN)-mediated double-strand break (DSB) formation at a pre-defined target genomic location using a unique intron directly downstream of a promoter driving a selectable marker gene to facilitate homology between target and donor sequences. In this system, only insertion into the target locus leads to a functional selectable marker, and regeneration from random insertions of the promoterless donor construct are reduced on selection media.

Positive and negative emotion in the daily life of dual-earner couples with children.

What is the emotional valence of family life and what factors contribute to this valence? Research indicates that most people are mildly happy but also that the years devoted to raising children are associated with diminished happiness and well-being, particularly for mothers. Public discourse is increasingly concerned that parenthood does not make us happy, but little empirical work has actually studied the emotional valence of family life. We addressed this gap in the literature with an intensive examination of the emotional valence of dual-earner family life.

A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression.

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of approximately 80% indicating a substantial genetic component. Population genetics and genome-wide association studies suggest an overlap of genetic risk factors between these illnesses but it is unclear how this genetic component is divided between common gene polymorphisms, rare genomic copy number variants, and rare gene sequence mutations. We report evidence that the lipid transporter gene ABCA13 is a susceptibility factor for both schizophrenia and bipolar disorder.

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G).

Angiographic assessment of initial balloon angioplasty results.

Purpose: To determine the influence of three factors involved in the angiographic assessment of balloon angioplasty-interobserver variability, operator bias, and the definition used to determine success-on the primary (technical) results of angioplasty in the peripheral arteries.

Materials And Methods: Percent stenosis in 107 lesions in lower-extremity arteries was graded by three independent, experienced vascular radiologists ("observers") before and after balloon angioplasty and their estimates were compared with the initial interpretations reported by the physician performing the procedure ("operator") and an automated quantitative computer analysis. Observer variability was measured with use of intraclass correlation coefficients and SD.

A geometric theory of chaotic phase synchronization.

A rigorous mathematical treatment of chaotic phase synchronization is still lacking, although it has been observed in many numerical and experimental studies. In this article we address the extension of results on phase synchronization in periodic oscillators to systems with phase coherent chaotic attractors with small phase diffusion. As models of such systems we consider special flows over diffeomorphisms in which the neutral direction is periodically perturbed.