Publications by authors named "Margaret B Zhong"
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over the course of disease development. The literature provides some evidence of sex-specific contributions to AD. However, molecular mechanisms of sex-biased differences in AD remain elusive.
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- Defects in the endo-lysosomal autophagy and ubiquitin-proteasome systems contribute to the development and progression of Alzheimer's Disease (AD), as evidenced by early pathological changes like enlarged endosomal compartments and accumulation of autophagic vacuoles.
- Genetic variants in important regulators of these degradation pathways are linked to AD, as well as abnormal expression levels of key proteins in human brain tissues and mouse models of the disease.
- Understanding the dysregulation of these protein degradation pathways and exploring targeted therapies could lead to new treatment options for AD, necessitating further research on the molecular mechanisms involved and the key components of these systems.
The apolipoprotein E4 (ApoE4) genotype combines with traumatic brain injury (TBI) to increase the risk of developing Alzheimer's Disease (AD). However, the underlying mechanism(s) is not well-understood. We found that after exposure to repetitive blast-induced TBI, phosphoinositol biphosphate (PIP) levels in hippocampal regions of young ApoE3 mice were elevated and associated with reduction in expression of a PIP degrading enzyme, synaptojanin 1 (synj1).
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