Proc Natl Acad Sci U S A
October 2023
Coordinated expression of ion channels is crucial for cardiac rhythms, neural signaling, and cell cycle progression. Perturbation of this balance results in many disorders including cardiac arrhythmias. Prior work revealed association of mRNAs encoding cardiac Na1.
View Article and Find Full Text PDFVoltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in neurons. The human genome includes ten human VGSC α-subunit genes, SCN(X)A, encoding Na1.1-1.
View Article and Find Full Text PDFCatastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding and channels ( and , respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single-molecule fluorescence localization approaches, we find that roughly half the translational complexes contain transcripts.
View Article and Find Full Text PDFAnn Clin Transl Neurol
June 2019
Pathogenic loss-of-function variants in are linked to Dravet syndrome (DS). Previous work suggested that neuronal pathfinding defects underlie epileptogenesis and SUDEP in the null mouse model of DS. We tested this hypothesis by inducing deletion in adult mice that had developed normally.
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