Publications by authors named "Margaret A Chase"
Objectives: Assess the overall level of burnout in pediatric critical care medicine fellows and examine factors that may contribute to or protect against its development.
Design: Cross-sectional observational study.
Setting: Accreditation Council for Graduate Medical Education-accredited pediatric critical care medicine fellowship programs across the United States.
Article Synopsis
- Researchers studied Hsp72 levels in RSV-infected human bronchial cells and tracheal samples from children, finding that Hsp72 is released and increases cytokine production in neutrophils.
- The study revealed that Hsp72 activates neutrophils through the NF-kappaB pathway, demonstrating its role beyond being just an intracellular protein.
Heat shock proteins are generally regarded as intracellular proteins acting as molecular chaperones; however, Hsp72 is also detected in the extracellular compartment. Hsp72 has been identified in the bronchoalveolar lavage fluid (BALF) of patients with acute lung injury. To address whether Hsp72 directly activated airway epithelium, human bronchial epithelial cells (16HBE14o-) were treated with recombinant Hsp72.
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