Publications by authors named "Marengo G"
Coronary artery calcification is a complex anatomical and histological pathology with different pathways that contribute to calcium deposit and calcification progression. As part of the atherosclerotic process, extensive calcifications are becoming more common and are associated with poorer PCI outcomes if not properly addressed. Since no drug has shown to be effective in changing this process once it is started, proper knowledge of the underlying pathogenesis and how to diagnose and manage it is essential in contemporary coronary intervention.
View Article and Find Full Text PDFPurpose: Existing resources that characterize the essentiality status of genes are based on either proliferation assessment in human cell lines, viability evaluation in mouse knockouts, or constraint metrics derived from human population sequencing studies. Several repositories document phenotypic annotations for rare disorders; however, there is a lack of comprehensive reporting on lethal phenotypes.
Methods: We queried Online Mendelian Inheritance in Man for terms related to lethality and classified all Mendelian genes according to the earliest age of death recorded for the associated disorders, from prenatal death to no reports of premature death.
Ultrathin-strut drug-eluting stents (DES) have been related to potential improvement in stent-related outcomes compared with thicker-struts DES. However, comparisons among different ultrathin devices are lacking. All randomized controlled trials comparing ultrathin (struts thickness <70 µm) and thicker-struts DESs in an all-comers population were included.
View Article and Find Full Text PDFEssential genes are those whose function is required for cell proliferation and/or organism survival. A gene's intolerance to loss-of-function can be allocated within a spectrum, as opposed to being considered a binary feature, since this function might be essential at different stages of development, genetic backgrounds or other contexts. Existing resources that collect and characterise the essentiality status of genes are based on either proliferation assessment in human cell lines, embryonic and postnatal viability evaluation in different model organisms, and gene metrics such as intolerance to variation scores derived from human population sequencing studies.
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- A study found that using Quantitative Flow Ratio (QFR) for virtual angioplasty before and after PCI (Percutaneous Coronary Intervention) led to better outcomes than traditional angiographic methods, but there is a lack of correlation between pre-PCI QFR and post-PCI FFR (Fractional Flow Reserve).
- The study involved 84 patients with significant coronary lesions, focusing on measuring various flow ratios before and after the procedure, with an average age of 65.5 years and a majority having lesions in the left anterior descending artery.
- Despite achieving procedural success and improvements in post-PCI FFR, the pre-PCI QFR did not show reliable correlation with the post-PCI FFR, indicating
Article Synopsis
- The study investigates how gender affects heart remodeling and the risk of heart failure (HF) after acute coronary syndrome (ACS), using data from the CORALYS registry.
- Among 14,699 patients, 31% were women, who had different health profiles compared to men, showing higher rates of hypertension and diabetes but lower rates of smoking and previous heart attacks.
- Results indicated that women had a higher incidence of both HF hospitalizations and cardiovascular death, establishing female sex as an independent risk factor for these outcomes after ACS.
Article Synopsis
- The study investigates the risk factors for hospitalization due to heart failure (HF) in patients with acute coronary syndrome (ACS) who have not previously experienced HF or left ventricular dysfunction.
- It analyzed data from 14,699 patients across 16 European centers using both Cox regression and machine learning models, identifying key risk factors such as reduced renal function and left ventricular ejection fraction.
- The CORALYS HF score successfully pinpointed high-risk patients using commonly available information at discharge, indicating a need for further strategies to prevent HF in this specific group.
Background: Transcatheter aortic valve replacement (TAVR) in non-calcified aortic regurgitation (NCAR) is an off-label procedure. The balloon-expandable Myval includes extra-large sizes (30.5 mm and 32 mm) of interest in this setting.
View Article and Find Full Text PDFBackground The impact of complete revascularization (CR) on the development of heart failure (HF) in patients with acute coronary syndrome and multivessel coronary artery disease undergoing percutaneous coronary intervention remains to be elucidated. Methods and Results Consecutive patients with acute coronary syndrome with multivessel coronary artery disease from the CORALYS (Incidence and Predictors of Heart Failure After Acute Coronary Syndrome) registry were included. Incidence of first hospitalization for HF or cardiovascular death was the primary end point.
View Article and Find Full Text PDFBackground: In patients with ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) of the culprit lesion significantly reduces the risk of cardiovascular death. However, the management of non-culprit lesions in patients with the multivessel disease remains a matter of debate in this setting. It's still unclear if a morphological OCT-guided approach, identifying coronary plaque instability, may provide a more specific treatment compared with a standard angiographic/functional approach.
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- Patients with a history of acute coronary syndrome (ACS) have a high risk of recurring cardiovascular issues, and recent therapies aim to lower these risks but may increase bleeding.
- In a study of over 10,000 ACS patients, it was found that 53.4% qualified for the PEGASUS strategy, while 38.2% were eligible for the COMPASS strategy, with a notable overlap of 34.4% between the two.
- Overall, about one-third of the patients could benefit from either prolonged dual antiplatelet therapy or dual pathway inhibition, indicating varying eligibility for these treatments among ACS patients.
Background: Previous studies investigating predictors of Heart Failure (HF) after acute coronary syndrome (ACS) were mostly conducted during fibrinolytic era or restricted to baseline characteristics and diagnoses prior to admission. We assessed the incidence and predictors of HF hospitalizations among patients treated with percutaneous coronary intervention (PCI) for ACS.
Methods And Results: CORALYS is a multicenter, retrospective, observational registry including consecutive patients treated with PCI for ACS.
Introduction: Despite limited to short and midterm outcomes, valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) has emerged as a valid alternative to re-surgical aortic valve replacement (re-SAVR) for high- and intermediate-risk patients with degenerated surgical bioprosthesis.
Methods: All studies comparing multivariate adjustment between ViV TAVI and re-SAVR were screened. The primary end-points were all-cause and cardiovascular (CV) mortality at 30 days and at Midterm follow-up.
Article Synopsis
- * Results showed a TLR incidence of 2.5% overall and a major adverse clinical event (MACE) rate of 9.4%, with postdilation and provisional stenting contributing to lower TLR rates.
- * The findings suggest that thin-strut DES provide a reliable treatment option for bifurcation cases, while certain procedural techniques can enhance outcomes.
Background: Comparative data after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for unprotected left main coronary artery (ULMCA) disease according to lesion site (ostial/shaft vs distal) are scant. The aim of this meta-analysis was to investigate outcomes after PCI or CABG for ULMCA disease according to lesion site.
Methods: Randomized controlled trials (RCTs) and adjusted observational studies that compared PCI versus CABG in patients with ULMCA disease and reported outcomes according to lesion site were systematically identified.
Introduction And Objectives: Coronary artery calcium (CAC) score improves the accuracy of risk stratification for atherosclerotic cardiovascular disease (ASCVD) events compared with traditional cardiovascular risk factors. We evaluated the interaction of coronary atherosclerotic burden as determined by the CAC score with the prognostic benefit of lipid-lowering therapies in the primary prevention setting.
Methods: We reviewed the MEDLINE, EMBASE, and Cochrane databases for studies including individuals without a previous ASCVD event who underwent CAC score assessment and for whom lipid-lowering therapy status stratified by CAC values was available.
Long term survival and its determinants after Percutaneous Coronary Intervention (PCI) on Unprotected Left Main Coronary Artery (ULMCA) remain to be appraised. In 9 European Centers 470 consecutive patients performing PCI on ULMCA between 2002 and 2005 were retrospectively enrolled. Survival from all cause and cardiovascular (CV) death were the primary end points, while their predictors at multivariate analysis the secondary ones.
View Article and Find Full Text PDFBackground: The placebo effect is a well described phenomenon in blinded studies evaluating antianginal therapeutics, although its effect on clinical research metrics remains unknown. We conducted a systematic review and meta-analysis to quantify the effect of placebo on end points of symptoms, life quality, and functional outcomes in randomized placebo-controlled trials (RCTs) of symptomatic stable coronary artery disease.
Methods: We systematically reviewed MEDLINE, EMBASE, and the Cochrane database for double-blind RCTs of antiangina therapeutics.
Introduction: Recently, observational data have raised concerns about safety of selfexpandable (SE) compared to balloon-expandable (BE) valves in TAVI, although potentially limited by patient selection bias.
Methods: All Randomized Controlled Trials (RCTs) comparing BE vs. SE TAVI or/and vs.
Background: Clinical benefits of FFR (Fraction Flow Reserve) driven CABG (Coronary Artery Bypass Graft) remain to be established.
Methods: All randomized controlled trials (RCTs) and observational studies with multivariable adjustement were included. MACE (Major Adverse Cardiac Events) was the primary end point, while its single components (death, myocardial infarction, and total vessel revascularization [TVR]) along with number of anastomoses, on pump procedures and graft occlusion at angiographic follow-up were the secondary ones.
Objective: We aimed to evaluate whether electrophysiological auditory thresholds (EATs) before 3 month of age, as assessed by the auditory brainstem responses (ABR) test and the auditory steady state responses (ASSR) test, can predict hearing outcome at 3 years of age among children born with congenital cytomegalovirus (cCMV) infection.
Study Design: Audiological assessment was performed before 3 months of age, and every 6 months thereafter until 3 years of age, in a population of 63 children (126 ears). EATs before 3 months of age and at 3 years of age were compared.