Publications by authors named "Maren Scharfenberger-Schmeer"
Infection of grapevines with the grey mold pathogen Botrytis cinerea results in severe problems for winemakers worldwide. Browning of wine is caused by the laccase-mediated oxidation of polyphenols. In the last decades, Botrytis management has become increasingly difficult due to the rising number of resistances and the genetic variety of Botrytis strains.
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- The study examines how light exposure, specifically from a UV-C source, affects the formation of 2-aminoacetophenone from tryptophan in wine, influenced by oxygen levels and transition metals.
- More light exposure and higher oxygen concentrations led to increased levels of 2-aminoacetophenone, while transition metals slowed its formation and indicated a competing reaction involving acetaldehyde.
- The research highlights the importance of oxygen, not only in the degradation of riboflavin but also in enhancing the light-induced formation of 2-aminoacetophenone, providing new insights into riboflavin's role in these reactions.
Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly altered genomic regions point to candidate genes involved in leukemogenesis, we used microarray-based comparative genomic hybridization and single nucleotide polymorphism profiling data of 391 AML cases to further narrow down genomic regions of interest. Targeted resequencing of 1000 genes located in the critical regions was performed in a representative cohort of 50 AML samples comprising all major cytogenetic subgroups.
View Article and Find Full Text PDFBackground: Today, mutations in more than 30 different genes have been found to cause inherited cardiomyopathies, some associated with very poor prognosis. However, because of the genetic heterogeneity and limitations in throughput and scalability of current diagnostic tools up until now, it is hardly possible to genetically characterize patients with cardiomyopathy in a fast, comprehensive, and cost-efficient manner.
Methods And Results: We established an array-based subgenomic enrichment followed by next-generation sequencing to detect mutations in patients with hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).