Publications by authors named "Maren Romeyke"
The structural models created to understand the cytoskeletal mechanics of cells in suspension are described here. Suspended cells can be deformed by well-defined surface stresses in an Optical Stretcher [Guck, J., Ananthakrishnan, R.
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- The study investigates how suspended cells respond to step stress, highlighting a passive relaxation process due to a cross-linked actin structure beneath the membrane.
- The transition from fluid to solid state aligns with the unbinding times of cross-linking proteins, showing that elastic effects from entangled filaments are minimal.
- The symmetry of suspended cells leads to consistent viscoelastic properties, unlike adherent cells, influencing how different cell types respond to mechanical stimuli over time.
The relationship between the mechanical properties of cells and their molecular architecture has been the focus of extensive research for decades. The cytoskeleton, an internal polymer network, in particular determines a cell's mechanical strength and morphology. This cytoskeleton evolves during the normal differentiation of cells, is involved in many cellular functions, and is characteristically altered in many diseases, including cancer.
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