Publications by authors named "Maren Q DeGottardi"
Article Synopsis
- IL-15 is involved in both hyperimmune activation and the support of NK and T cell functions during HIV/SIV infections, impacting host immunity.
- Two groups of SIV-infected rhesus macaques were treated with an IL-15-neutralizing antibody, leading to significant depletion of NK cells and some CD8 T cells, but not affecting overall SIV replication or CD4 T cell loss.
- The treatment accelerated the reactivation of rhadinovirus, suggesting that while IL-15 does not play a critical role in SIV dynamics, it may still help control certain viral infections.
IL-15 has been implicated as a key regulator of T and NK cell homeostasis in multiple systems; however, its specific role in maintaining peripheral T and NK cell populations relative to other γ-chain (γc) cytokines has not been fully defined in primates. In this article, we address this question by determining the effect of IL-15 inhibition with a rhesusized anti-IL-15 mAb on T and NK cell dynamics in rhesus macaques. Strikingly, anti-IL-15 treatment resulted in rapid depletion of NK cells and both CD4(+) and CD8(+) effector memory T cells (TEM) in blood and tissues, with little to no effect on naive or central memory T cells.
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