Publications by authors named "Maren Bauer"
Article Synopsis
- Mandelic acid, an important chemical, is mainly produced through chemical synthesis, but recent advancements have allowed for its production using engineered microbial fermentation that avoids competing byproducts.
- To develop a more efficient production strain that does not require external tyrosine, three engineering strategies were tested: adjusting the enzyme HmaS to reduce its binding to a competing substrate, relocating biosynthesis enzymes to specific cellular compartments, and using a modified bifunctional enzyme PheA.
- The best results came from using the modified PheA, which led to a 12-fold increase in mandelic acid production without the need for tyrosine supplementation, showing potential for other industrial applications reliant on phenylalanine derivatives.
DSMZ16671 Reduces Mutans Streptococci: A Short-Term Pilot Study.
Probiotics Antimicrob Proteins
January 2013
Reducing the burden of pathogenic mutans streptococci is a goal of oral health. DSMZ16671, even after heat-killing, specifically co-aggregates mutans streptococci in vitro and retains this activity in human saliva. In rats, it reduces mutans streptococcal colonization of teeth and caries scores.
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