Publications by authors named "Marella Marassi"
Article Synopsis
- MODY (maturity-onset diabetes of the young) includes genetic forms of diabetes often misdiagnosed as type 1 or type 2 diabetes, with diagnosis relying primarily on genetic testing due to varying clinical features.
- ABCC8-MODY is a subtype caused by mutations in the ABCC8 gene, affecting insulin secretion, and presenting a complex range of symptoms with unclear genotype-phenotype links.
- Effective treatment primarily involves sulfonylureas targeting the defective gene product, but their effectiveness can vary; more research is needed to better understand ABCC8-MODY and the implications of different genetic variants.
Background And Aims: An acute depletion of circulating haematopoietic stem/progenitor cells (HSPCs) occurs during COVID-19, especially among patients with a poorer disease course. We herein examined whether HSPCs levels at hospital admission for COVID-19 predict 1-year mortality and the long-COVID syndrome.
Materials And Methods: Patients hospitalized for COVID-19 in an infectious disease ward were consecutively enrolled.
Aim/hypothesis: We examined whether prediction of long-term kidney outcomes in individuals with type 2 diabetes can be improved by measuring circulating levels of haematopoietic stem/progenitor cells (HSPCs), which are reduced in diabetes and are associated with cardiovascular risk.
Methods: We included individuals with type 2 diabetes who had a baseline determination of circulating HSPCs in 2004-2019 at the diabetes centre of the University Hospital of Padua and divided them into two groups based on their median value per ml of blood. We collected updated data on eGFR and albuminuria up to December 2022.
Type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease (CKD), are recognized among the most disruptive public health issues of the current century. A large body of evidence from epidemiological and clinical research supports the existence of a strong interconnection between these conditions, such that the unifying term cardio-metabolic-renal (CMR) disease has been defined. This coexistence has remarkable epidemiological, pathophysiologic, and prognostic implications.
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