Vnímání rizika antibiotické rezistence a znalost principů racionální ATB preskripce mezi českými praktickými lékaři - závěry z pilotního šetření.

The issue of antibiotic resistance stands as one of the foremost contemporary global challenges in healthcare. This study presents findings from a pilot survey conducted among Czech general practitioners, concentrating on their perception of antibiotic resistance risk and their knowledge of the AWaRe classification. This classification, in accordance with international guidelines, serves as the principal indicator for monitoring the quality of antibiotic prescriptions.

[COVID-19: diagnosis and treatment].

The guidelines provide evidence-based recommendations for the management of COVID-19. The clinical manifestations of the disease are described and indication criteria for hospital admission of patients with COVID-19 are listed. Polymerase chain reaction and antigen testing are used in direct diagnostics.

[Vaccination against COVID-19].

Vaccination is essential to manage the COVID-19 pandemic. Vaccination significantly protects against severe COVID-19, hospitalization and death; it also protects against symptomatic infection and reduces the risk of transmission to other people. Protection against the new SARS-CoV-2 variants may be lower, but protection against severe course and death remains high.

[Manual for physicians in COVID-19 units].

The manual contains basic information about the diagnosis, treatment and organization of care for COVID-19 patients staying in general wards.

[COVID-19: diagnosis and treatment outside hospital].

COVID-19 is an acute infectious disease, predominantly affecting the respiratory tract, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Calprotectin and calgranulin C serum levels in bacterial sepsis.

The aim of this study was to evaluate the serum levels of calprotectin and calgranulin C and routine biomarkers in patients with bacterial sepsis (BS). The initial serum concentrations of calprotectin and calgranulin C were significantly higher in patients with BS (n = 66) than in those with viral infections (n = 24) and the healthy controls (n = 26); the level of calprotectin was found to be the best predictor of BS, followed by the neutrophil-lymphocyte count ratio (NLCR) and the level of procalcitonin (PCT). The white blood cell (WBC) count and the NLCR rapidly returned to normal levels, whereas PCT levels normalized later and the increased levels of calprotectin, calgranulin C, and C-reactive protein persisted until the end of follow-up.

[The challenges of diagnostic reasoning or "how doctors think"].

Basic overview of diagnostic errors with particular focus on cognitive biases and strategies to minimize or avoid them.

[Outpatient parenteral antibiotic therapy (OPAT)].

Traditionally, parenteral (i. e. intravenous) antimicrobial therapy has been used in inpatients with various bacterial infections.