Blackberry Leaves as New Functional Food? Screening Antioxidant, Anti-Inflammatory and Microbiological Activities in Correlation with Phytochemical Analysis.

Blackberry fruits are recognized as functional foods while blackberry leaves are outside this classification and they also contain active compounds with health-promoting potential. Therefore, the aim of this study was the phytochemical analysis of blackberry leaves of varieties (Chester, Loch Ness, Loch Tay and Ruczaj) and screening of their biological activity (antioxidant potential, possibility of inhibition of enzymes, anti-inflammatory and microbial activity). The following compounds from selected groups: phenolic acids (caffeic acid, ellagic acid, gallic acid, syringic acid), flavonols (quercetin, kaempferol) and their glycosides (rutin, isoquercetin, hyperoside) and flavon-3-ols (catechin, epicatechin) were chromatographically determined in the aqueous and hydroalcoholic leaves extracts.

Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Extract with Potential for Dental Applications.

root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied.

Potential Salivary Markers for Differential Diagnosis of Crohn's Disease and Ulcerative Colitis.

The properties of the saliva of patients with inflammatory bowel disease (IBD) are poorly recognized. Likewise, the diagnostic potential of saliva for differentiating various forms of IBD is largely unexplored. Therefore, we compared the concentrations of several parameters in unstimulated whole mixed saliva collected in a standardized manner from patients with active IBD unresponsive to conventional therapy.

Resistance of IoT Sensors against DDoS Attack in Smart Home Environment.

Smart devices along with sensors are gaining in popularity with the promise of making life easier for the owner. As the number of sensors in an Internet of Things (IoT) system grows, a question arises as to whether the transmission between the sensors and the IoT devices is reliable and whether the user receives alerts correctly and in a timely manner. Increased deployment of IoT devices with sensors increases possible safety risks.

PHARMACEUTICAL CARE FORM APPLICATION IN ELDERLY PATIENTS RESEARCH.

Many patients, especially elderly, very often don't inform family physicians about drugs prescribed by other specialist and use a number of preparations to self-medicate. These actions may supply negative consequences in recovery process and can be significantly reduced through the implementation of a well-run pharmaceutical care (PC) in the community pharmacy. Therefore, it is necessary to design proper PC documentation, which allows for comprehensive gathering information needed to carry out the analysis of relevant factors impacting on the prescribed pharmacotherapy effectiveness.

Electron Paramagnetic Resonance of a Single NV Nanodiamond Attached to an Individual Biomolecule.

Electron paramagnetic resonance (EPR), an established and powerful methodology for studying atomic-scale biomolecular structure and dynamics, typically requires in excess of 10(12) labeled biomolecules. Single-molecule measurements provide improved insights into heterogeneous behaviors that can be masked in ensemble measurements and are often essential for illuminating the molecular mechanisms behind the function of a biomolecule. Here, we report EPR measurements of a single labeled biomolecule.

PHYSICIANS' VALUATION OF INDIVIDUAL MEDICATION MANAGEMENT SYSTEM (IMMS) IMPLEMENTATION IN POZNAŃ (POLAND) COMMUNITY PHARMACIES.

The reason of growing Pharmaceutical Care (PC) popularity in Poland and all over the world in recent years is connected with a new idea which separates pharmacists from a stereotype of drug store, dealing only with issuing medicines in adequate doses. There is an intention of emphasizing their qualifications and maximizing the use of them. One of the essential part of PC is preparing Individual Medication Management System (IMMS) which may provide individualized pharmacotherapy for patient.

Physicians' and patients' valuation of pharmaceutical care implementation in Poznan (Poland) community pharmacies.

Implementation of pharmaceutical care (PC) in Poland is of great importance to patients, who, on the one hand, often follow complex pharmacological treatment regimens recommended by several physicians of different specialties, and, on the other, take up the decision on self-treatment due to availability of OTC medications. The aim of the present study was to assess the opinion of both patients and physicians about implementation of PC service in Polish community pharmacies. A cross sectional study was carried out from September 2009 to September 2010 by a pharmacist (author of the study) on the basis of an anonymous questionnaire, where demand of physicians (n = 104) and patients (n = 202) for implementation of PC in a community pharmacy was assessed.

Individual medication management system (IMMS) implementation in pharmacists' opinion.

Many countries of the world including Poland, are taking actions for improving the role of the pharmacist as a health care professional. One of those is implementation of pharmaceutical care (PC), as a documented specialist medical service, which also includes pharmacist interventions, such as preparing Individual Medication Management System (IMMS), to enhance patient's adherence. Because of the chance to monitor the dosage and to detect and prevent drug problems occurrence, IMMS is thought to be an opportunity for individualized, effective and safe patient's pharmacotherapy.

Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure.

Nucleosomes contain ∼146 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility to transcription and repair complexes. Posttranslational modification (PTM) of histone proteins regulates nucleosome function. To date, only modest changes in nucleosome structure have been directly attributed to histone PTMs.

Individual medication management system (IMMS) as a proposition of obeying the doctor's recommendation with pharmacist cooperation.

The pharmacist is an expert with the knowledge of drugs, who has a possibility to follow the patient's individual pharmacotherapy, which is the basis of the pharmaceutical care programme. The implementation of the Individual Medication Management System (IMMS) may be one of the proposals which will enable an analysis of the course of pharmacotherapy and elimination of drug problems, which are the chief goals of pharmaceutical care. In order to determine community pharmacy patients' degree of interest in the IMMS and to evaluate the degree of patients' discipline concerning the application of doctors' recommendations they were given an anonymous questionnaire.

[Aging of prokaryotic organisms].

Until recently it was thought that aging is a characteristic feature only of cells and organisms of eukaryotic origin. Recent studies on Caulobacter crescentus showed that their dimorphic life cycle associated with asymmetric cell division leads to a gradual increase in the time needed for the development of new bacteria generations, which may reflect aging of this organism. Moreover, as shown in Escherichia coli, accelerated exhaustion of proliferative capacity and bacteria death are caused by inheritance of certain structures from the mother cell during cell division.

Histone fold modifications control nucleosome unwrapping and disassembly.

Nucleosomes are stable DNA-histone protein complexes that must be unwrapped and disassembled for genome expression, replication, and repair. Histone posttranslational modifications (PTMs) are major regulatory factors of these nucleosome structural changes, but the molecular mechanisms associated with PTM function remains poorly understood. Here we demonstrate that histone PTMs within distinct structured regions of the nucleosome directly regulate the inherent dynamic properties of the nucleosome.

Peritoneal effects of intravenous iron sucrose administration in rats.

Intravenous iron supplementation is commonly used in uremic patients treated with peritoneal dialysis. Infusion of iron compounds results in various systemic noxious effects, mainly because of its prooxidant and proinflammatory actions. The authors studied how the intravenous infusion of iron sucrose (IS) affects intraperitoneal homeostasis in rats undergoing acute peritoneal dialysis.