The Surgical Management of Severe Scoliosis in Immature Patient with a Very Rare Disease Costello Syndrome-Clinical Example and Brief Literature Review.

Costello syndrome (CS) is a rare genetic syndrome in which, due to the occurrence of a mutation in the HRAS gene on chromosome 11 that causes the manifestation, a set of features such as a characteristic appearance, many congenital defects, intellectual disability and a genetic predisposition to cancer, friendly personality, and others can be identified. CS is very rare, with an incidence of ~1/300,000, but it belongs to one of the largest groups of congenital syndromes, called RASopathies, occurring with an incidence of 1/1000 people. Scoliosis and kyphosis, as well as other spinal defects, are common, in 63% and 58% of patients, respectively, and a study conducted among adult patients showed the presence of scoliosis in 75% of patients; there may be excessive lordosis of the lumbar section and inverted curvatures of the spine (lordosis in the thoracic section and kyphosis in the lumbar section).

Magnetic resonance imaging (MRI) for assessment of differences in geometrical parameters in muscles stabilizing vertebral column in young and older persons. Case study.

Today non-traumatic low back pain (LBP) is a social disease being attributed to weakening the function of abdominal and back muscles. Condition of deep muscles, inaccessible to non-invasive examinations, can be assessed by means of magnetic resonance imaging (MRI). The method allows for the assessment of cross-sections, muscle girths, as well as their intensity (brightness).