Mathematical Modeling of Breast Tumor Destruction Using Fast Heating during Radiofrequency Ablation.

In oncology, hyperthermia is understood as a planned, controlled technique of heating cancerous changes in order to destroy their cells or stop their growth. In clinical practice, hyperthermia is used in combination with radiotherapy, chemotherapy, or immunological therapy. During the hyperthermia, the tissue is typically exposed to a temperature in the range of 40-45 °C, the exception is thermoablation, during which the temperatures reach much higher values.

Hyperthermia process control induced by the electric field in order to destroy cancer.

Purpose: The paper presents numerical modeling of the artificial hyperthermia induced by the electric field in order to destroy the abnormal tissue. In particular, the possibility of process control in order to increase the temperature of only the tumor tissue was discussed. Due to the fact that the external electrodes which generate the additional heat, heat not only the area of the tumor, but also healthy tissue which surrounds the tumor, increasing the temperature inside the cancer is possible by introducing the paramagnetic nanoparticles into the interior.

The modelling of heating a tissue subjected to external electromagnetic field.

The boundary element method (BEM) is used to solve the coupled problem connected with the biological tissue heating. The tissue treated as a non-homogeneous domain (healthy tissue and tumor region) is subjected to external electromagnetic field. The thermal effect is produced by electrodes that touches the skin surface.