[Production of proinflammatory cytokines by peripheral blood mononuclear cells in cocultures with squamous cell carcinoma of the larynx].

Purpose: Antitumor mechanisms of cellular immune response are connected with the cytokines activity secreted by peripheral blood mononuclear cells (PBMC). The aim of this study was estimation of proinflammatory cytokine (IL-6 and TNF- ) concentration in patients with laryngeal squamous cell carcinoma and analysis of directed influence of neoplasm cells to the function of PBMC and modification of cytokine profile.

Materials And Methods: For analysis of cytokine secretion, the cultures of isolated peripheral blood mononuclear cells (PBMC) with marginal neoplasm cells and noncancerous adjacent mucosa cells from 55 patients with laryngeal squamous cell carcinoma were established.

[Expression of transcription nuclear factor NFkappaB in laryngeal carcinoma tumor cells--correlation with IL-10 expression by blood mononuclear cells and clinicomorphological features].

Purpose: Transcription nuclear factor NFkappaB (p65-p50/RelA) is an activator of transcription process and regulates the apoptosis, cell cycle, proliferation, secretion of cytokines, angiogenic and growth factors by initiation gene transcription. NFkappaB can be activated by signaling pathway following IL-10 stimulation. The aim of this study was to estimate NFkappaB cytoplasmic and nuclear immunoexpression and to analyze the connection with clinicopathological features and IL-10 concentration produced by blood mononuclear cells in patients with laryngeal carcinoma.

The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma.

Suppressor of cytokine signaling 1 (SOCS1) is the key regulator of cytokine-mediated innate and adaptive immunity. One of the molecular mechanisms of SOCS1 is connected with inhibition of TLR4-NFkappaB pathway. The relationships among these molecules in laryngeal carcinoma are not exactly known.

EGFR immunoexpression and peripheral blood cytokine secretion as potential biomarkers of tumor behavior in laryngeal squamous cell carcinoma.

Background: Epidermal growth factor receptor (EGFR) and proinflammatory cytokines have been implicated in the dysregulated cell growth and increased aggressiveness of human cancers. The purpose of this study was to analyze EGFR immunoexpression in neoplastic tissues and IL-6 and TNFalpha secretion by peripheral blood mononuclear cells (PBMCs) and to investigate their relationships with certain clinicopathological characteristics.

Material/methods: Tumor expression of membranous and cytoplasmic EGFR was measured in 45 cases of laryngeal squamous cell carcinoma by IHC staining.

[Clinical ocular-motor disturbances in multiple sclerosis].

Unlabelled: Otoneurologic bedside examination with testing eye movements gives valuable information about static and dynamic properties of balance system and may give topodiagnostyc information about the side of lesion in patients with vertigo, dizziness and disequilibrium.

The Aim Of The Study: was to present the scheme of otoneurological bedside examination and usefulness of ocular motor disturbances index in evaluation of Multiple Sclerosis patients status.

Material And Methods: Sixty patients with diagnosis of MS, seen in outpatient neurology clinic, Medical University of Lodz, from 2002 to 2004, were enrolled into the study.

[The rare case of metastasis to lumbar part of spinal column from laryngeal cancer].

A rare case of distant metastasis to spinal column--lumbar vertebra (L5)--from laryngeal cancer was reported. It must be noted that in 10% of cases metastases to vertebral column are first symptom of a neoplastic disease and sixty-five percent of patients with advanced cancer present bone metastases. Metastatic involvement of the bone is one of the most frequent causes of pain in cancer patients and represents one of the first signs of widespread neoplastic disease.

[Expression of activation antigens on the lymphocytes T in patients with carcinoma of the larynx and connection with tumor features].

Introduction: Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect. Atcivation of lymhocytes T is connected with expression the markers (antigens) on their surface. The aim of this study was the analysis of activation antigens expression on lymphocytes T in patients with laryngeal carcinoma and the connection with clinicomorphological features.

Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal squamous cell carcinoma.

Stimulation of epidermal growth factor receptor (EGFR) results in the activation of signal transducer and activator of transcription-3 (STAT3), a transcriptional factor associated with carcinogenesis. Proinflammatory cytokines are capable of activating a tumor cell death program by reducing EGFR tyrosine phosphorylation. This study aimed to identify EGFR expression in laryngeal carcinoma and determine the relationship with STAT3 and proinflammatory/regulatory cytokine secretion.

[Diagnostic and therapeutic problems in parapharyngeal space tumor--case report].

Only 0.5% of head and neck tumors originate from parapharyngeal space. Malignant neoplasms of parapharyngeal space are exceptionally rare (20% of all tumors in this area).

[Results of treatment papilloma of nasal cavity and paranasal sinuses].

Introduction: Papilloma of the nose and paranasal sinuses is a benign tumor originated from nose mucosa. Especially inverted papilloma tumor has a significant recurrence and malignancy potential rate. The aim of the study was the analysis of clinical and treatment outcomes of patients with papilloma of the nose and paranasal sinuses.

[Tumors of the parotid gland--management and results of surgical treatment].

Introduction: Tumors of the salivary glands are uncommon and represent 2-4% of head and neck neoplasms. Most tumors originate in the parotid gland, from which 10 to 15% are found to be malignant. Different methods of surgical treatment can be performed depending on the type, localization and size of tumor.

[Production of cytokines by peripheral blood mononuclear cells--correlation with clinicomorphological features in laryngeal carcinoma].

Introduction: In studied analyzed role of the cytokines in pathology of neoplasms of various origin the importance of these proteins in regulation of immunocompetent cells function has been described. The aim of this study was to estimate of cho sen cytokines concentration produced by peripheral blood mononuclear cells and in whole blood in patients with laryngeal carcinoma and to analyze the connection of cytokines profile with clinicopathological features. MATERIALA AND METHODS: 55 patients with squamous cell carcinoma of the larynx treated at ENT Department Medical University of Lodz between 2003-2007 were analyzed.

[Solitary fibrous tumor of the nasal cavity, paranasal sinuses and anterior fossa].

Solitary fibrous is rare mesenchymal neoplasm that usually arises in the pleura or less commonly is related to other serosal surfaces. There were reported SFTs in some extrapleural locations. There locations cause diagnostic difficulties.

[Juvenile angiofibroma in adults].

Introduction: Juvenile nasopharyngeal angiofibroma is a benign lesion which is characterized by three distinctive features: it occurs only in one sex, one period of age and in one location in the organism.

Material And Method: Basing on literature and our series concerning 36 patients treated during 50 years, we present atypical cases of angiofibroma. All of them accomplished patomorphological and clinical criteria of this neoplasm, beside of age and sex.

[Vascular malformation of the head and neck--diagnosis and treatment].

Unlabelled: Vascular malformations are the most common anomalies appearing from birth to any adulthood. They are not clinically and morphologically homogenous group. They may occur at different place but most often in the subcutaneous or submucous space in the oral cavity, pharynx, the paranasal sinuses and nose.

[Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma].

Introduction: Occult foci of neoplasm cells in lymph nodes (referred to as micrometastases) in various squamous cell carcinomas may be discovered by immunohistochemistry by using anti-CKs (cytokeratine filaments) policlonal antibodies which reactive with epithelial cells. Matrix metalloproteinases (MMPs) are proteolytic family enzymes represent a group of endopeptidases which are capable to degrading components of the extracellular matrix and have been implicated as playing an important role in cancer invasion and metastases. The purpose of this study was to analyze the morphological parameters and to investigate MT1-MMP expression in laryngeal carcinoma to relate the expression to CKs in pN0 lymph nodes.

[Clinico-histopathological characteristic of inverted papilloma of nasal cavity and paranasal sinuses cases treated in Department of Laryngological Oncology UM of Lodz between 2002-2006--review of latest literature].

Authors introduced diagnostic procedures, clinico-morphological features and treatment results of 16 cases of nasal cavity and paranasal sinuses inverted papillomas treated surgically on Department of Laryngological Oncology of Medical University of Lodz between 2002-2006. References review, definition, classification, clinico-hiostopathological criteria and treatment methods of Schneiderian papilloma were introduced in study.

Identification of internuclear ophthalmoplegia signs in multiple sclerosis patients. Saccade test analysis.

Background And Purpose: Patients with multiple sclerosis (MS), due to the diverse nature of the disease, have many types of eye movement disorders, particularly internuclear ophthalmoplegia (INO). The aim of the study was to evaluate the usefulness of a quantitative statistical saccade test analysis for identification of INO in MS patients.

Methods: Sixty MS patients and 50 volunteers underwent clinical bedside ocularmotor examination and electrooculographic evaluation in a tertiary referral university hospital.

[Production of proinflammatory cytokines IL-6 and IL-8 by peripheral blood lymphocytes T under influence in vitro of squamous cell carcinoma of the larynx].

Aim: The most important mechanism of host humoral immunity in antitumor response is cytokines activity produced by T lymphocytes. The aim of this preliminary study was estimation of IL-6 and IL-8 serum concentration in patients with squamous cell laryngeal carcinoma and analysis of indirect influence of neoplasm cells to the function of T lymphocytes and modification of proinflammatory cytokines profile.

Materials And Methods: 7 patients with squamous cell carcinoma of the larynx treated at ENT Department Medical University of Lodź between 2003-2005 were analyzed.

[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx].

Unlabelled: Matrix metalloproteases (MMPs) are proteolytic enzymes contribute to tumor expansion by degrading components of the extracellular matrix. MPPs play a key role in tumor invasion and metastases of various cancers and head and neck carcinoma as well. The aim of this study was to investigate MT1-MMP expression in squamous cell carcinoma of the larynx to relate these levels of expression to clinicohistological features of the tumor and lymph nodes e.

[Preseptal orbital abscess as a post-traumatic late complication--review of the literature and case report].

Preseptal orbital cellulitis and orbital abscess are rare post-traumatic late orbital complications. Authors reported a case of anterior orbital abscess following craniofacial trauma in a 47-year-old men. Diagnostic procedures, therapeutic intervention were presented and literature reviewed.

[Cytokeratin antigen expression in lymph nodes--prognostic significance of clinical features of the primary tumor and lymph nodes in the presence of micrometastases in laryngeal carcinoma].

Lymph node micrometastases in patients with squamous cell carcinoma of the larynx found node-negative by conventional histology may be discovered by immunohistochemistry, particularly by using mono- and policlonal antibodies which are reactive with epithelial cells. Then tumors classified as pN0 by routine methods may be reclassified more correctly as pN1. Authors investigated the incidence of micrometastases in the neck dissection specimens originally staged as pN0 from 22 patients with laryngeal cancer treated surgically at ENT Department Medical University of Lodz between 1998-1999 according to: the survival, using immunostaining with panel of mono- and policlonal antibodies to cytokeratins CK1, CK4, CK5, CK6, CK8, CK10, CK13 and CK18.

[Hemangioma cavernous of the nasal cavity and the maxillary sinus--case report and review of the literature].

Hemangiomas of the nasal cavity and especially paranasal sinuses are very rare. Authors reported a case of hemangioma cavernous of the nasal cavity and maxillary sinus in a 34-year-old women. Diagnostic procedures, therapeutic intervention were presented and literature reviewed.

[Palatine tonsils colonization with actinomyces species during chronic tonsillitis].

The Actinomysec spp. are common saprophytic microorganisms which are found in the oral cavity, pharynx and palatine tonsils. The actinomycotic infections can be responsible for recurrent chronic tonsillitis.

[Electronystagmographic outcome of visual ocular-motor tests in normal individuals of different ages].

Elektronystagmographic outcome of visual ocular-motor tests (smooth pursuit, optokinetic, saccadic) in 67 healthy subjects in different age were used for quantitative analysis. Three groups were studied: 16 young (29.8 +/- 5.