Non-parametric MRI Brain Atlas for the Polish Population.

The application of magnetic resonance imaging (MRI) to acquire detailed descriptions of the brain morphology is a driving force in brain mapping research. Most atlases are based on parametric statistics, however, the empirical results indicate that the population brain tissue distributions do not exhibit exactly a Gaussian shape. Our aim was to verify the population voxel-wise distribution of three main tissue classes: gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF), and to construct the brain templates for the Polish (Upper Silesian) healthy population with the associated non-parametric tissue probability maps (TPMs) taking into account the sex and age influence.

Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy.

Purpose: In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the classic threshold method with a linear interpolation and those previously published for the blood measurements.

Materials And Methods: 9 patients suffering from HIE aged from 65 to 80 months were included in the study.

Whole Brain and Cranial Size Adjustments in Volumetric Brain Analyses of Sex- and Age-Related Trends.

Our goal was to determine the influence of sex, age and the head/brain size on the compartmental brain volumes in the radiologically verified healthy population (96 subjects; 54 women and 42 men) from the Upper Silesia region in Poland. The MRI examinations were done using 3T Philips Achieva with the same T1-weighted and T2-weighted protocols. The image segmentation procedures were performed with SPM (Statistical Parameter Mapping) and FSL-FIRST software.

Application of high field magnetic resonance microimaging in polymer gel dosimetry.

Purpose: The purpose of this work was to examine the suitability of VIPAR polymer gel-9.4 T magnetic resonance microimaging system for high spatial resolution dose distribution measurements.

Methods: The VIPAR samples (3 cm in outside diameter and 12 cm in height) were exposed to ionizing radiation by using a linear accelerator (Varian TrueBeam, USA; 6 MV x-ray beam).

NMR-based metabolomics in pediatric drug resistant epilepsy - preliminary results.

Epilepsy in children is the most frequent, heterogeneous and difficult to classify chronic neurologic condition with the etiology found in 35-40% of patients. Our aim is to detect the metabolic differences between the epileptic children and the children with no neurological abnormalities in order to define the metabolic background for therapy monitoring. The studied group included 28 epilepsy patients (median age 12 months) examined with a diagnostic protocol including EEG, videoEEG, 24-hour-EEG, tests for inborn errors of metabolism, chromosomal analysis and molecular study.

Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies.

Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia.

Mathematical evaluation of melatonin secretion in hypoxic ischemic encephalopathy.

Objectives: The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis.

Methods: Thirty one professional ballet dancers and twenty eight controls completed five walking trials at their preferred speed. Kinematic data in the basic anatomical planes for ankle, knee, and hip joints as well as for the pelvis were collected with an optoelectronic motion system.

Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion.

The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome ( = 9) and in children with ( = 80) and without ( = 40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion. The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and the shape parameter allow analyzing the fit and deducing about how much the measured melatonin profile differs from a physiological bell-shaped secretion. The estimated sleep duration and phase shift of melatonin release as well as the DMLO offsets at 25% and 50% relative thresholds are the key characteristic of Angelman syndrome children.

Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods.

. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. .

Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion.

Purpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods.

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.

The ability of hematopoietic stem cells (HSCs) to self-renew is a prerequisite for the establishment of definitive hematopoiesis and life-long blood regeneration. Here, we report the single-stranded DNA-binding transcriptional regulator far upstream element (FUSE)-binding protein 1 (FUBP1) as an essential factor of HSC self-renewal. Functional inactivation of FUBP1 in two different mouse models resulted in embryonic lethal anemia at around E15.