AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.

Antibiotic-resistant superbug bacteria represent a global health problem with no imminent solutions. Here we demonstrate that the combination (termed AB569) of acidified nitrite (A-NO) and Na-EDTA (disodium ethylenediaminetetraacetic acid) inhibited all Gram-negative and Gram-positive bacteria tested. AB569 was also efficacious at killing the model organism in biofilms and in a murine chronic lung infection model.

Monomer- and polymer radicals of vinyl compounds: EPR and DFT studies of geometric and electronic structures in the adsorbed state.

Electron paramagnetic resonance (EPR) spectroscopy was applied to study the paramagnetic species formed from styrene, 1,1-diphenylethylene, α-methylstyrene, β-methylstyrene and methylmethacrylate adsorbed on amorphous silica gel after γ-irradiation at 77K. Radicals formed by the hydrogen atom addition at the vinyl group of the monomers were observed in all samples. The hydrogen atoms were shown to originate to a large extent from the adsorbent by using silica gel with deuterated silanol groups.

In-Depth Profiling of Degradation Processes in a Fuel Cell: 2D Spectral-Spatial FTIR Spectra of Nafion Membranes.

We present in-depth profiling by micro FTIR of cross sections for Nafion 115 membranes in membrane-electrode assemblies (MEAs) degraded during 52 or 180 h at open circuit voltage (OCV) conditions, 90 °C and 30% relative humidity. Analysis of optical images showed highly degraded zones in both MEAs. Corresponding 2D FTIR spectral-spatial maps indicated that C-H and C═O groups are generated during degradation.

Visualizing chemical reactions and crossover processes in a fuel cell inserted in the ESR resonator: detection by spin trapping of oxygen radicals, nafion-derived fragments, and hydrogen and deuterium atoms.

We present experiments in an in situ fuel cell (FC) inserted in the resonator of the ESR spectrometer that offered the ability to observe separately processes at anode and cathode sides and to monitor the formation of HO and HOO radicals, H and D atoms, and radical fragments derived from the Nafion membrane. The presence of the radicals was determined by spin-trapping electron spin resonance (ESR) with 5,5-dimethylpyrroline N-oxide (DMPO) as a spin trap. The in situ FC was operated at 300 K with a membrane-electrode assembly (MEA) based on Nafion 117 and Pt as catalyst, at closed and open circuit voltage conditions, CCV and OCV, respectively.

Molecular sieves in medicine.

During the last few decades microporous and mesoporous materials have been considered for medical use due to biological properties and stability in biological environment. Zeolites have been investigated as drug carriers, and as adjuvants in anticancer therapy, dietetic supplements or antimicrobial agents. This review gives a brief overview of the major aspects of molecular sieves applications in medicine.

Determining the geometry and magnetic parameters of fluorinated radicals by simulation of powder ESR spectra and DFT calculations: the case of the radical RCF2CF2* in nafion perfluorinated ionomers.

The ESR spectrum of the chain-end radical RCF2CF2* detected in Nafion perfluorinated membranes exposed to the photo-Fenton reagent was accurately simulated by an automatic fitting procedure, using as input the hyperfine coupling tensors of the two F alpha and two F beta nuclei as well as the corresponding directions of the principal values from density functional theory (DFT) calculations. An accurate fit was obtained only for different orientations of the hyperfine coupling tensors for the two F alpha nuclei, indicating a nonplanar structure about the C alpha radical center. The fitted isotropic hyperfine splittings for the two F beta nuclei in the Nafion radical, 24.

Application of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders.

This review gives a brief overview over the major aspects of application of the nicotine alkaloid and its close derivatives in the therapy of some neurodegenerative disorders and diseases (e.g. Alzheimer's disease, Parkinson's disease, Tourette's syndrome, schizophrenia etc.

EPR and DFT study on the stabilization of radiation-generated methyl radicals in dehydrated Na-A zeolite.

Electron paramagnetic resonance (EPR) spectroscopy was applied to study paramagnetic species stabilized in Na-A zeolite exposed to gaseous methane and gamma-irradiated at 77 K. Two types of EPR spectra were recorded during thermal annealing of zeolite up to room temperature. Owing to the results for the zeolite exposed to (13)CH(4) the multiplet observed at 110 K was assigned to a (.

Multifrequency electron paramagnetic resonance study on deproteinized human bone.

Irradiated samples of deproteinized powdered human bone (femur) have been examined by electron paramagnetic resonance (EPR) spectroscopy in X, Q and W bands. In the bone powder sample only one type of CO2- radical ion is stabilized in the hydroxyapatite structure in contrast to powdered human tooth enamel, a material also containing hydroxyapatite, widely used for EPR dosimetry and in which a few radicals are stable at room temperature. It is suggested that the use of deproteinized bone for EPR dosimetry could improve the accuracy of dose determination.