Publications by authors named "Marek Benes"
Purpose: Obesity and its related severe comorbidities are increasing rapidly. The duodenal-jejunal bypass is an endoscopically implanted device (mimicking the Roux-en-Y gastric bypass) developed to support weight reduction and improve type 2 diabetes control.
Materials And Methods: Retrospective data analysis of consecutive patients undergoing duodenal-jejunal bypass (EndoBarrier®, DJB) implantation between 2013 and 2017 was performed to evaluate safety as well as short- and long-term efficacy.
Background: The endoscopically implanted duodenal-jejunal bypass liner (DJBL) is an attractive alternative to bariatric surgery for obese diabetic patients. This article aims to study dynamical aspects of the glycaemic profile that may influence DJBL effects.
Methods: Thirty patients underwent DJBL implantation and were followed for 10 months.
Backround: Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening.
Aim: To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC).
Methods: From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine.
Context: Neudesin has recently been identified as a novel regulator of energy expenditure in experimental animals; however, its role in humans remains unexplored.
Objective: The aim of this study was to assess the effects of obesity and type 2 diabetes mellitus (T2DM) along with selected weight reducing interventions on serum neudesin levels and adipose tissue mRNA expression.
Patients And Methods: Fifteen obese subjects with T2DM undergoing endoscopic duodenal-jejunal bypass liner (DJBL) implantation, 17 obese subjects (11 with T2DM, 6 without T2DM) scheduled for gastric plication (GP), 15 subjects with functional hypoglycemia subjected to 72-hour acute fasting (AF), and 12 healthy controls were included in the study.
This paper analyses the performance of SampEn and one of its derivatives, Fuzzy Entropy (FuzzyEn), in the context of artifacted blood glucose time series classification. This is a difficult and practically unexplored framework, where the availability of more sensitive and reliable measures could be of great clinical impact. Although the advent of new blood glucose monitoring technologies may reduce the incidence of the problems stated above, incorrect device or sensor manipulation, patient adherence, sensor detachment, time constraints, adoption barriers or affordability can still result in relatively short and artifacted records, as the ones analyzed in this paper or in other similar works.
View Article and Find Full Text PDFHypothalamic dysfunction leading to severe obesity is a serious long-term consequence of paediatric craniopharyngioma. It compromises quality of life, leads to long-term metabolic hazards, and may shorten life expectancy. Therefore, a proactive approach is required.
View Article and Find Full Text PDFArticle Synopsis
- The duodenal-jejunal bypass liner (DJBL) is a noninvasive device aimed at mimicking gastrointestinal bypass surgery by preventing food contact with the duodenum and proximal jejunum.
- A study involving 30 obese patients with poorly controlled type 2 diabetes mellitus (T2DM) showed that DJBL implantation led to reduced body weight, improved lipid levels, and better glucose regulation over 10 months.
- Following removal of the DJBL, participants experienced slight weight gain and deterioration in lipid levels, but the benefits in glucose control persisted, suggesting that increases in certain hormones and bile acids contributed to these positive outcomes.
Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES.
Gastroenterol Res Pract
July 2016
Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods.
View Article and Find Full Text PDFArticle Synopsis
- The study monitored the effectiveness of the infliximab biosimilar CT-P13 in treating patients with inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC), in the Czech Republic.
- Out of 52 patients treated, 50% of those with CD and 40.9% with UC achieved remission after 14 weeks, with significant improvements in disease activity indices and serum C-reactive protein levels.
- The study concluded that CT-P13 is effective in managing IBD, with a few reported adverse events, highlighting its potential as a treatment option.
Aim: To investigate perception of natural orifice transluminal endoscopic surgery (NOTES) as a potential technique for appendectomy.
Methods: One hundred patients undergoing endoscopy and 100 physicians were given a questionnaire describing in detail the techniques of NOTES and laparoscopic appendectomy. They were asked about the reasons for their preference, choice of orifice, and extent of complication risk they were willing to accept.
Background: Effective and safe access site closure is critical for clinical application of natural orifice transluminal endoscopic surgery.
Objective: The current study evaluated a simple novel technique of gastrotomy closure.
Design: Feasibility study with a survival animal model.
Objective: To investigate whether gastroesophageal reflux disease (GERD) with mild to moderate erosive esophagitis (ERD) is a more severe disease regarding the amount of acid reflux, motor abnormalities, and the presence/absence of hiatus hernia than non-erosive reflux disease (NERD).
Material And Methods: The study comprised a retrospective analysis of prospectively collected data on 313 consecutive subjects referred for endoscopy, pH-metry, and esophageal manometry. The patients were divided into four groups: Group I (n=92), subjects without GERD with normal pH-metry, without esophagitis and without reflux symptoms; Group II (n=111), patients with NERD (no esophagitis, abnormal pH-metry); Group III (n=77), patients with mild to moderate ERD (LA A, B; abnormal pH-metry); Group IV (n=33), patients with severe or complicated esophagitis (LA C, D; Barrett's esophagus).
Background: Proton pump inhibitors (PPIs) taken twice daily do not effectively control night-time intragastric pH; nocturnal acid breakthrough (NAB) (arbitrarily defined as intragastric pH < 4 lasting longer than 1 h) occurs in more than 75% of patients. The effectiveness of PPIs depends rather on the Helicobacter pylori status.
Objectives: To investigate the effectiveness of two regimens of omeprazole in H.