Robust boundary formation in a morphogen gradient via cell-cell signaling.

Establishing sharp and correctly positioned boundaries in spatial gene expression patterns is a central task in both developmental and synthetic biology. We consider situations where a global morphogen gradient provides positional information to cells but is insufficient to ensure the required boundary precision, due to different types of noise in the system. In a conceptual model, we quantitatively compare three mechanisms, which combine the global signal with local signaling between neighboring cells, to enhance the boundary formation process.

Self-organized system-size oscillation of a stochastic lattice-gas model.

The totally asymmetric simple exclusion process (TASEP) is a paradigmatic stochastic model for nonequilibrium physics, and has been successfully applied to describe active transport of molecular motors along cytoskeletal filaments. Building on this simple model, we consider a two-lane lattice-gas model that couples directed transport (TASEP) to diffusive motion in a semiclosed geometry, and simultaneously accounts for spontaneous growth and particle-induced shrinkage of the system's size. This particular extension of the TASEP is motivated by the question of how active transport and diffusion might influence length regulation in confined systems.