Publications by authors named "Marea V E van der Rijst"
Background: Vel expression on erythrocytes is variable due to polymorphisms, complicating Vel typing. Weak Vel expression can be caused by mutations within SMIM1 in a heterozygous setting, suggesting a dominant negative effect of SMIM1 mutants on wild type (wt)SMIM1 expression. Here we report how SMIM1 expression is regulated during erythropoiesis, to understand its variable expression on erythrocytes.
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- The study addresses the challenge of finding Vel-negative blood donors for patients with anti-Vel alloantibodies, as these donors are rare (1 in 4000).
- Researchers developed a recombinant anti-Vel monoclonal antibody that effectively identifies both Vel-negative and weak Vel-expressing red blood cells, surpassing existing human anti-Vel sera in accuracy.
- The new antibody (M3F5S-IgM) can be used in various testing methods, increasing the availability of Vel-negative blood donations by discovering new potential donors through high-throughput screening.