Publications by authors named "Mardini S"

Introduction: Assessing facial aesthetic surgery outcomes often relies on expert opinion, which inherently introduces bias. This study examined the use of artificial intelligence to objectively compare novel and standard brow lift techniques.

Methods: Fifty-nine patients who underwent brow lift surgery between 2006 and 2020 were divided into two groups: Group A (n = 47) underwent a standard brow lift, while Group B (n = 12) received our novel technique.

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Background: Controversy exists around the optimal timing of resection of nevus sebaceous (NS). The authors aim to determine optimal timing of NS resection and identify predictors of surgical outcomes and secondary intralesional neoplasms.

Methods: Retrospective chart review of all patients with biopsy-proven NS diagnosis treated at the authors' institution between 1987 and 2024.

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Purpose: To review cases of lateral brow dermoid cysts and gain insight into the utility of preoperative imaging, incidence of intraorbital extension, and recurrence rate.

Methods: This is a retrospective study of all patients who underwent excision of lateral brow dermoid cysts at the authors' academic center over a 37-year period.

Results: A total of 136 patients were included.

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Objective: The pattern, rate, and natural history of bone flap resorption following cranioplasty with frozen, autologous bone flap has not been fully defined. The authors sought to quantify the progression and natural history of bone flap resorption.

Methods: Patients who had craniectomy and delayed cranioplasty with stored, frozen bone flap between 2012 and 2022 were included in this study.

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Objective: Dermoid cyst (DC) is a congenital cyst with the potential to have intracranial extension (ICE). This study aims to evaluate the imaging yield and surgical outcomes of nasal, medial brow, forehead, and scalp DCs.

Design: Retrospective review of craniofacial DCs treated at our institution between 1992 and 2024.

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Article Synopsis
  • - The study investigates the effectiveness of endoscopic ultrasound (EUS)-guided celiac plexus block versus a sham procedure in alleviating abdominal pain for patients suffering from chronic pancreatitis, with the aim of determining pain reduction statistics.
  • - Conducted as a randomized sham-controlled trial, the research will involve multiple academic sites and focus on patients whose chronic pancreatitis is confirmed by EUS diagnostic criteria, measuring outcomes like pain reduction through specific pain assessment tools.
  • - The ultimate goal is to provide a clear evaluation of celiac plexus block’s efficacy compared to a placebo treatment, which may help in managing chronic pain related to pancreatitis more effectively.
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  • The study aims to improve health literacy for cleft lip and palate patients by using OpenAI's ChatGPT-4 to make patient educational materials (PEMs) easier to read.
  • PEMs were evaluated for interactive content, with readability assessed before and after AI modifications, resulting in significant improvements from a 9th-grade to a 6th-grade reading level.
  • Despite enhancements in readability, only 27% of the websites included interactive educational tools, highlighting a gap that needs to be addressed to improve patient education and engagement.
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  • Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive skin cancer with a high recurrence rate, particularly challenging when it occurs on the scalp due to its potential to invade deeper structures like bone and brain.
  • A study of 33 patients treated for DFSP at a tertiary center analyzed demographics, imaging results, and surgical outcomes to evaluate the effectiveness of preoperative imaging (CT and MRI) in guiding treatment.
  • The findings indicated that while imaging has low sensitivity and negative predictive value for identifying periosteal invasion, it shows high specificity and positive predictive value, making it valuable for surgical planning and reconstruction.
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  • Aging of the face involves complex three-dimensional changes across five layers of facial anatomy, influenced by various factors over time.
  • New research has identified key structures and led to the development of pharmacologic agents aimed at reversing signs of aging, alongside traditional treatments like botulinum toxin and fillers.
  • Effective antiaging treatments require a deep understanding of the aging process and should be personalized based on individual patient characteristics and desired outcomes.
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Importance: Since 2005, a total of 50 face transplants have been reported from 18 centers in 11 countries. The overall survival of the grafts has not yet been established.

Objective: To assess the survival of the face transplant grafts and evaluate factors potentially influencing it.

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Peripheral nerve repair is daily activity for several microsurgeons. Numerous nerve repair techniques are applied, including neurorrhaphy, nerve grafting and nerve transfer, depending on the nature and extent of the injury. However, these techniques become unfeasible when the distal nerve end is not preserved during the peripheral nerve injury or a segment of the muscle is transferred without the nerve supplying it.

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  • This study reviews the use of free flap reconstruction for patients with cleft palates who have persistent oronasal fistulas, gathering data on various flap types and surgical outcomes.
  • A systematic review included 23 retrospective case studies, encompassing 65 patients with an average age of 19.3 years and a common use of the radial forearm flap.
  • Results indicated a low rate of complications, with only 13.8% experiencing recurrent fistulas and significant speech improvement noted in many cases.
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For some patients who have lost the lower part of an arm, hand transplant offers the possibility of receiving a new limb with varying degrees of sensation and function. This procedure, Vascularized Composite Allotransplantation (VCA), is demanding for patients and their care community and comes with significant risks. As a high-stakes decision, patients interested in VCA are subject to extensive clinical evaluation and eligibility decision making.

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Total and permanent loss of facial and nonfacial fat is a rare side effect of immune checkpoint inhibitors (ICIs). Consequently, effective treatment modalities for patients remain undefined. Here, we discuss the surgical treatment of a patient with both ICI-related acquired generalized lipodystrophy (AGL).

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A multigene phylogenetic assessment of North American species of is presented based on analyses of ITS, and 28S rDNA nucleotide data. This framework enables a systematic revision of the genus for 16 eastern North American species and captures taxonomic and phylogenetic diversity in a global context. A grade of two unusual and poorly known North American species stems from the most recent common ancestor of the genus that gives rise to three core subgroups named here as clades Unicolores, Nothosperma, and Mallocybe.

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Background: Eyelid ptosis may present with upper lid dermatochalasis and brow ptosis. When indicated, ptosis correction (PC) is advocated during upper blepharoplasty (UB). In this study, the authors aimed to report their outcomes following UB and PC.

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Background: Malignant peripheral nerve sheath tumors (MPNSTs) are rare yet highly aggressive soft tissue sarcomas of mesenchymal origin, characterized by a heterogeneous pathological spectrum, limited therapeutic options, and high metastatic potential.

Methods: Here, the authors conducted a comprehensive bibliometric analysis of the 100 most-cited MPNST articles by utilizing Elsevier's Scopus to identify all relevant published and indexed articles referring to MPNST, thereby aiming to elucidate the pertinent research findings regarding the disease's pathophysiology and therapeutic advancements. Articles were classified as basic science or clinical and analyzed for various bibliometric parameters.

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Large animal models are essential to research in facial paralysis, face transplant, craniofacial surgery, and ophthalmology. Pigs are a well-studied species with high similarity to human anatomy and physiology for these research areas. However, in contrast to cats and dogs protecting the cornea and eye is difficult in swine due to the inability to use an Elizabethan collar (E-collar) and the complexity of placing and maintaining a temporary tarsorrhaphy for corneal protection due to the strength of the pig levator muscle.

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Background: Dynamic facial reanimation is the gold standard treatment for a paralyzed face. The use of the cross-face nerve graft (CFNG) in combination with the masseteric nerve to innervate the free gracilis muscle has been reported to provide both spontaneity and strong neural input. We report a case series of dual innervation, using a novel method where the branch to masseter is coapted to the side of the CFNG.

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After a transnasal endoscopic resection of a high-grade adenoid cystic carcinoma that underwent adjuvant chemoradiation, there was delayed recurrence managed by en bloc resection through an open craniofacial approach. Subsequently, the patient developed a chronic nasocranial fistula with secondary infection and bone flap resorption. This resulted in infectious episodes with secondary scalp incisional dehiscence and hardware exposure which required multiple bone debridement procedures, hardware removal, prolonged IV antibiotics, and hyperbaric oxygen treatment.

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Background: Nerve transfer from the masseteric branch of the trigeminal nerve is a widely performed procedure for facial reanimation. Despite achieving powerful muscle force, clinical and aesthetic results leave room for improvement. Preclinical animal models are invaluable to establishing new therapeutic approaches.

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Tweetable abstract Emerging targeted therapies offer hope for malignant peripheral nerve sheath tumor. Innovative drug delivery enhances potential treatments. #MPNST #TargetedTherapies #TherapeuticDelivery.

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The latissimus dorsi muscle is the workhorse flap for intrathoracic reconstruction. Prior thoracotomy, which divides the latissimus dorsi muscle, limits the muscle's intrathoracic reach. We present our experience using the distal portion of the muscle for intrathoracic reconstruction based off an intercostal vessel.

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