[Change in urea-forming function of rat liver in the acute and recovery period after radiation exposure].

The results of investigations of some metabolites and enzymes of ornithine cycle in total gamma-irradiated rats are presented. It is shown that ionizing radiation furthers the intensification of liver ammonium binding function. It took place without visible enzyme activation during the first period of defeat.

[State of the urea-producing function of the liver in gamma-irradiated rats].

The investigations of some metabolites and enzymes of ornithine cycle in irradiated rats were performed. It was shown that ionizing radiation furthered the intensification of liver ammonium-connecting function. It took place without visible enzyme activation during the first period of defeat.

[Metabolic characteristics of the myocardium and muscle tissue of the thigh in rats].

Myocardium and skeletal muscle of white rats have a number of specific features in metabolism of carbohydrates. The skeletal muscle is characterized by high intensity of glycolytic processes and glycolytic substrate phosphorylation, that is testified to by the activity of the terminal glycolysis stage enzymes (pyruvate kinase, lactate dehydrogenase, its isoenzyme spectrum) and by the content of lactate and pyruvate metabolites. In contrast to skeletal muscles, the activity of NAD-dependent malate dehydrogenase in the myocardium is significant both in cytoplasm and in mitochondria.

[Changes in the spectrum of LDH isoenzymes in foci of epileptic activity induced by penicillin in the cerebral cortex of rats].

The correlation between electrophysiological changes and isozymes of LDH of the rat brain cortex was studied in seizure foci induced by application of sodium penicillin. It was discovered that activity of LDH1 was suppressed, and that of LDH5 fraction was elevated in the determinant focus, which indicates the enhanced glucose anaerobic transformation. The spectrum of LDH isozymes did not practically differ from the indicators in control animals in a homotopic region of the contralateral hemisphere prior to creation of the mirror focus.

[Lactate dehydrogenase isoenzyme spectrum in the myocardium and skeletal muscles of animals under physical stress].

Single physical load (forced run up to fatigue) changes the lactate dehydrogenase activity in the myocardium and skeletal muscles of rats. It is pronounced in a sharp rise of the activity 1 h after the action, in a decrease 6 h after and again in an increase a day later and a gradual fall on the third seventh days. An increase in the portion of isoenzymes typical of the anaerobic metabolism is peculiar to the myocardium and skeletal muscles, that finds its manifestation in both an increase in the lactic acid amount and the lactate/pyruvate coefficient.