Co-existence of two antibiotic-producing marine bacteria: reduce gene expression and production of the antibacterial compound, tropodithietic acid, in sp.

Many bacteria co-exist and produce antibiotics, yet we know little about how they cope and occupy the same niche. The purpose of the present study was to determine if and how two potent antibiotic-producing marine bacteria influence the secondary metabolome of each other. We established an agar- and broth-based system allowing co-existence of a species and that, respectively, produce tropodithietic acid (TDA) and bromoalterochromides (BACs).