Publications by authors named "Marcus Svedberg"
Objectives: Telehealth and home spirometry feasibility for children has been established, but their impact on cystic fibrosis (CF) disease progression remains unassessed. We aimed to evaluate the effects of telehealth and home spirometry on CF disease progression and care.
Methods: Children with CF aged 5-17 years from all Swedish CF centers were provided with home spirometers.
Article Synopsis
- - The study examined the effects of lumacaftor/ivacaftor on lung function and microbial presence in cystic fibrosis (CF) patients homozygous for F508del over one year.
- - Results showed significant improvements in lung function (ppFEV1) and body mass index (BMI) among both adults and children and a reduction in the prevalence of certain CF-related respiratory microorganisms.
- - However, key pathogens did not show significant changes, indicating that while some improvements were seen, the overall microbiological burden may not have diminished as expected.
Article Synopsis
- Aspergillus fumigatus is a common fungus found in the lungs of cystic fibrosis patients, and this study aimed to explore its impact on lung function, identify risk factors for colonization, and assess treatments for asymptomatic cases.
- Data was collected from a CF registry between 2014-2018, showing that 14.6% of patients became colonized, with inhaled antibiotics linked to higher colonization rates, but no significant decline in lung function was noted for colonized patients.
- Treatment of asymptomatic A. fumigatus did not show clear benefits, as those who received antifungal therapy experienced a more significant decline in lung function compared to untreated individuals.
Aim: Annual chest X-ray is recommended as routine surveillance to track cystic fibrosis (CF) lung disease. The aim of this study was to investigate the clinical utility of chest X-rays to track CF lung disease.
Methods: Children at Gothenburg's CF centre who underwent chest X-rays, multiple breath washouts and chest computed tomography examinations between 1996 and 2016 were included in the study.
Background: Computed tomography (CT) is used to monitor progression of structural lung disease (SLD) in children with cystic fibrosis (CF). Our goals were to identify the risk factors for the annual progression of SLD and the impacts of airway pathogens on SLD.
Method: Seventy-five school-aged children diagnosed with CF underwent 200 CT scans at Gothenburg CF Centre in the period 2003-2015.
Background: Data on long term variability of Lung Clearance Index (LCI) in Cystic Fibrosis (CF) is urgently needed to guide test result interpretation. Our aim was to evaluate LCI variability in clinically stable CF lung disease in school age children.
Methods: Paediatric patients, aged 6 to 17years, attending the outpatient CF clinic performed Multiple Breath Nitrogen Washout (Exhalyzer® D) and spirometry every third month over a period of one year.
The aim was to investigate the relationship between life events and social phobia. An inventory assessing life events during childhood, adulthood as well as life events experienced in relation to the onset of the disorder was administrated to 30 subjects with a DSM-IV diagnosis of social phobia. They were recruited by announcement and diagnosed by the Structured Clinical Interview for DSM-IV for axes I and II disorders.
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