Publications by authors named "Marcus Speyrer"
Article Synopsis
- A new usage for silver collagen oxidized regenerated cellulose (ORC) dressings combined with negative pressure wound therapy (NPWT) has been established, aiming to improve wound care.
- An in-person meeting with 7 healthcare providers sought to create guidelines regarding the effective use of these dressings in different clinical settings, leading to the development of consensus statements.
- Recommendations support the use of these dressings for various wounds like traumatic and diabetic ulcers, but advise against their use in specific situations such as exposed organs or vessels, and in cases of certain patient sensitivities.
Objective: To compare the effectiveness of a temporary topical external haemostat (OMNI-STAT Granules, Omni-stat Medical Inc., US) versus the use of electrocautery for bleeding control in patients who have undergone surgical wound debridement. Time saved in the operating room (OR) was evaluated.
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- A pandemic caused by the SARS-CoV-2 virus began in late 2019 in Wuhan, China, leading to over two million infections and more than 160,000 deaths worldwide, with severe cases often requiring mechanical ventilation.
- Various treatments have been studied, but no definitive evidence shows that any one drug is effective for COVID-19.
- In a small case series, five patients with COVID-19 underwent hyperbaric oxygen therapy (HBOT), leading to improvements in oxygen levels and overall recovery without mechanical ventilation.
Impaired wound healing is estimated to affect about 2% of the US population, and a major goal of health care providers (HCPs) is to better understand delayed healing so they can effectively choose advanced wound dressings to manage these wounds. However, there are estimated to be more than 3000 dressing options available, making dressing selection an overwhelming burden. An expert panel of 7 HCPs experienced in diverse medical disciplines and 3 scientists convened to discuss the use of 2 families of dressings (silver-oxysalt [AgOx] dressings and oxidized regenerated cellulose/collagen [ORC/C] dressings) and delayed wound healing.
View Article and Find Full Text PDFBackground: Biofilm can impair wound healing by maintaining an elevated, but ineffective, inflammatory state. This article describes interim results from the prospective RESPOND postmarketing registry evaluating the use of a native type 1, porcine collagen matrix with the embedded antimicrobial polyhexamethylene biguanide (PCMP) in the management of chronic wounds.
Methods: Adults ≥18 years of age with ≥1 appropriate wound were eligible for inclusion.
Article Synopsis
- The use of ultra-portable, mechanically powered disposable negative pressure wound therapy (dNPWT) is increasing for managing wounds in outpatient care and transitioning inpatients to home care, showing similar effectiveness to electric versions.
- Very few studies exist on best practices for dNPWT across different wound types, indicating a need for comprehensive clinical guidelines and knowledge on reimbursement processes.
- A panel of experts has developed recommendations for using dNPWT, including optimal patient selection, wound preparation, and reimbursement guidelines, aimed at improving clinical outcomes and economic value.
Article Synopsis
- The prevalence of wounds is rising, leading to more patients requiring wound care transition between different healthcare settings, which presents challenges in therapy and dressing options.* -
- A panel meeting was held to establish best practices for transitioning wound care, recommending NPWT for contaminated wounds and ORC/C/silver-ORC dressings for managing bleeding and promoting healing.* -
- Key factors for successful patient transition from inpatient to outpatient care include overall health, wound complexity, and access to services, along with addressing challenges in patient adherence and equipment troubleshooting.*
Article Synopsis
- Healthcare systems face challenges with nonhealing wounds, and ORC/collagen dressings may provide an effective, cost-efficient solution for wound management.
- A multidisciplinary panel of 15 wound care experts reviewed literature about ORC/collagen dressings, finding most studies had low evidence quality and discussing specific wound types that could benefit from this dressing.
- The panel provided recommendations on using ORC/collagen dressings, highlighted potential barriers, and called for more clinical and economic comparisons with standard wound care practices.
Hyaluronic acid (HA), the main component of extracellular matrix, is considered one of the key players in the tissue regeneration process. It has been proven to modulate via specific HA receptors, inflammation, cellular migration, and angiogenesis, which are the main phases of wound healing. Studies have revealed that most HA properties depend on its molecular size.
View Article and Find Full Text PDFIntroduction: Necrotizing fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic.
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