Virus-like particles: Next-generation nanoparticles for targeted therapeutic delivery.

Most drug therapies distribute the agents throughout the entire body, even though the drugs are typically only needed at specific tissues. This often limits dosage and causes discomfort and harmful side-effects. Significant research has examined nanoparticles (NPs) for use as targeted delivery vehicles for therapeutic cargo, however, major clinical success has been limited.

Characterization of [FeFe] Hydrogenase O2 Sensitivity Using a New, Physiological Approach.

[FeFe] hydrogenases catalyze rapid H production but are highly O-sensitive. Developing O-tolerant enzymes is needed for sustainable H production technologies, but the lack of a quantitative and predictive assay for O tolerance has impeded progress. We describe a new approach to provide quantitative assessment of O sensitivity by using an assay employing ferredoxin NADP reductase (FNR) to transfer electrons from NADPH to hydrogenase via ferredoxins (Fd).

Influence of chain length on the diffusion and electrophoresis of DNA adsorbed on heterogeneous supported lipid bilayers.

This manuscript describes the influence of chain length on the diffusion and electrophoresis of single stranded DNA (ssDNA) adsorbed on heterogeneous cationic supported lipid bilayers. These studies are motivated by the increasing interest in developing novel strategies for the separation of DNA. We studied ssDNA molecules with the number of bases (N) varying from 21 to 84.