Publications by authors named "Marcus Ling"
FDA-approved CAR T-cell Therapy: A Decade of Progress and Challenges.
Curr Pharm Biotechnol
July 2024
CAR T-cell therapy is a promising approach for cancer treatment, utilizing a patient's own T-cells (autologous cell) or T-cells from a healthy donor (allogeneic cell) to target and destroy cancer cells. Over the last decade, significant advancements have been made in this field, including the development of novel CAR constructs, improved understanding of biology and mechanisms of action, and expanded clinical applications for treating a wider range of cancers. In this review, we provide an overview of the steps involved in the production of CAR T-cells and their mechanism of action.
View Article and Find Full Text PDFArticle Synopsis
- The study is a retrospective cohort analysis aimed at understanding how body mass index (BMI) influences patient-reported outcomes after 1- and 2-level anterior cervical discectomy and fusion (ACDF) surgeries, amidst rising issues of cervical spondylosis and obesity among aging populations.
- A total of 878 patients were originally studied, but after exclusions (like prior surgeries or missing data), 535 were analyzed using various PRO measures collected at three different time points (preoperative, 6 months, and 2 years post-surgery).
- Results indicated that despite 48.3% of patients being obese, all groups showed significant improvements in PRO scores without major differences between BMI categories, although the highest reoperation rate
Myofascial compartments of the hand in relation to compartment syndrome: a cadaveric study.
Plast Reconstr Surg
February 2009
Background: Acute compartment syndrome of the hand is an emergency requiring prompt surgical decompression. This cadaveric study aims to identify the myofascial compartments of the hand by detailed dissection and direct visualization, to provide an accurate anatomical basis for surgical decompression.
Methods: Fourteen fresh-frozen cadaveric hands were dissected.