Publications by authors named "Marcus Kenyon"
Introduction: Axial spondyloarthritis (AxSpA) is a chronic inflammatory condition primarily affecting the axial skeleton. Peripheral features such as peripheral arthritis (PA) and dactylitis are common in AxSpA disease. This study aimed to investigate the independent impact of these manifestations on patient presentation and disease outcomes within an Irish AxSpA cohort.
View Article and Find Full Text PDFRecent studies have reported a negative association between exposure to childhood trauma, including physical neglect, and cognitive functioning in patients with schizophrenia. Childhood trauma has been found to influence immune functioning, which may contribute to the risk of schizophrenia and cognitive symptoms of the disorder. In this study, we aimed to test the hypothesis that physical neglect is associated with cognitive ability, and that this association is mediated by a combined latent measure of inflammatory response, and moderated by higher genetic risk for schizophrenia.
View Article and Find Full Text PDFArticle Synopsis
- Childhood trauma is linked to poorer cognitive function in schizophrenia, with inflammation and default mode network (DMN) connectivity playing key roles in this relationship.
- A study involving 53 patients with schizophrenia and 176 healthy participants found that low-grade inflammation, particularly IL-6 levels, was associated with altered DMN connectivity during a social cognition task.
- The research suggests that childhood neglect not only predicts higher IL-6 levels but also influences DMN connectivity, indicating a possible mechanism by which childhood trauma affects cognitive functioning in those with schizophrenia.
Background: Both low-grade systemic inflammation and functional connectivity of the default mode network (DMN) have recently been observed to mediate the association between childhood trauma (CT) and behavioural performance on an emotion recognition task. Whether inflammation also mediates the association between CT and functional connectivity of the DMN is unknown.
Methods: 51 patients with schizophrenia (SZ) or schizoaffective disorder (SZA) and 176 healthy participants completed a theory of mind (ToM) task during fMRI.
Ankylosing spondylitis (AS) is a seronegative, chronic inflammatory arthritis with high genetic burden. A strong association with HLA-B27 has long been established, but to date its contribution to disease aetiology remains unresolved. Recent insights through genome wide studies reveal an increasing array of immunogenetic risk variants extraneous to the HLA complex in AS cohorts.
View Article and Find Full Text PDFObjective: Exposure to childhood trauma (CT) is associated with cognitive impairment in schizophrenia, and deficits in social cognition in particular. Here, we sought to test whether IL-6 mediated the association between CT and social cognition both directly, and sequentially via altered default mode network (DMN) connectivity.
Methods: Three-hundred-and-eleven participants (104 patients and 207 healthy participants) were included, with MRI data acquired in a subset of n = 147.
Background: Individual genetic architecture is considered central to susceptibility and progression of disease in chronic pancreatitis. The study aimed to evaluate the presence of common pancreatic gene mutations in a defined cohort of idiopathic and alcohol-induced chronic pancreatitis patients in Ireland.
Methods: The study comprised patients with idiopathic and alcohol-induced chronic pancreatitis and historic controls.