Congenital Zika virus infection impacts on male mouse offspring's reproductive biology.

In Brief: Congenital ZIKV infection promotes alarming effects on male offspring's reproductive biology. This study showed the presence of the ZIKV antigen in the testis parenchyma, decreased testosterone levels, and sperm abnormalities in male offspring born to infected mothers.

Abstract: Infection with ZIKV during pregnancy is associated with fetal developmental problems.

GATA-1 mutation alters the spermatogonial phase and steroidogenesis in adult mouse testis.

GATA-1 is a transcription factor from the GATA family, which features zinc fingers for DNA binding. This protein was initially identified as a crucial regulator of blood cell differentiation, but it is currently known that the Gata-1 gene expression is not limited to this system. Although the testis is also a site of significant GATA-1 expression, its role in testicular cells remains considerably unexplored.