Protease inhibitor effects on prevalence of bacterial vaginosis and human papillomavirus-related lesions.

Aim: Antiretrovirals of the protease inhibitor (PI) class tend to achieve low concentrations in biological fluids. This study aimed to analyze possible changes in the vaginal microbiome and frequency of cervical human papillomavirus (HPV)-DNA and HPV-related lesions associated with the use of PI in antiretroviral therapy (ART).

Methods: Eighty-eight women with human immunodeficiency virus infection were divided in two groups: ART with PI and without PI.