Publications by authors named "Marcos Otavio Brum Antunes"
Introduction: Nationwide databases from large countries may provide real-world evidence about COVID-19 vaccine effectiveness (VE). This study sought to assess the VE of BNT162b2 and CoronaVac against COVID-19-related severe outcomes in school-aged children and adolescents during the Omicron wave of the COVID-19 pandemic in Brazil.
Methods: A nationwide population-based cohort study compared the incidence risk ratios (IRRs) of hospitalization due to COVID-19-associated severe acute respiratory syndrome (SARS), need for invasive ventilatory support, and death among school-aged children (age 5 to 11 years) and adolescents (age 12 to 17 years), stratified by vaccination status (none, one, or two doses), in 2022.
Article Synopsis
- The study analyzed the seasonality of acute bronchiolitis hospitalizations in infants in Brazil from 2020 to 2022, comparing it with data from previous years.
- The research found a dramatic 97% decrease in hospitalizations during strict COVID-19 measures but a subsequent 95% rise after these measures were relaxed, leading to an overall 16% increase in hospitalizations.
- In 2022, the seasonal pattern for acute bronchiolitis re-emerged, peaking in May, indicating a significant relationship between COVID-19 interventions and respiratory illnesses in young children.
Objective: Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in the lungs. Despite significant progress in developing CF transmembrane conductance regulator-specific treatments for CF lung disease, exploring alternative CF-targeted medications seems reasonable. We sought to evaluate the potential beneficial effects of oral benzbromarone as an adjuvant therapy in CF patients with reduced lung function.
View Article and Find Full Text PDFBackground: Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and paracrine inflammation; and obesity has been associated with premature immunosenescence, microbial translocation, and dysfunctional innate immune responses leading to poor immune response against a range of viruses and bacterial infections. Here, we have comprehensively characterized the immunosenescence, microbial translocation, and immune dysregulation established in hospitalized COVID-19 patients with different degrees of body weight.
View Article and Find Full Text PDFBackground: Asthma control is not well reflected by spirometry, yet this is the most frequently used measure of lung function in asthma clinics. Oscillometry is an alternative technique suitable for those with severe asthma.
Objective: To investigate usefulness of oscillometry in subjects with severe asthma to determine which outcome variables best reflected asthma control.