Publications by authors named "Marcos Lima"

Introduction: This study evaluated the impact of dealcoholized red wine polyphenols on the inflammation and lesion volume associated with apical periodontitis (AP) in rats.

Methods: Thirty-two Wistar rats receiving AP induction were arranged as follows: Control Group, Dealcoholized Red Wine Group (DRW), Red Wine Group, and Alcohol Group (ALC). Solutions were administered daily in a volume of 4.

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This study investigated the efficacy of an innovative edible coating, composed of fungal chitosan and alginate, functionalized with LC03, in both free and microencapsulated forms, to extend the shelf life and enhance the nutritional value of strawberries. LC03 cells were successfully encapsulated in alginate microparticles (MAL) and further coated with chitosan (MALC), resulting in enhanced protection (cell reduction below 1.4 CFU/mL), viability (8.

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Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group.

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5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dysbiosis and inflammatory bowel diseases. We investigated the effect of on 5-FU intestinal mucositis in mice.

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The microencapsulation of Lactocaseibacillus rhamnosus GG in a matrix of sodium alginate, xanthan gum, gum arabic and chitosan hydrochloride is a promising strategy for protecting this probiotic during passage through the gastrointestinal tract. This study evaluated the influence on the viability of Lactocaseibacillus rhamnosus GG encapsulated with these polymers by external ionic gelation with vibratory extrusion and the microcapsules that showed the best results of capsulation efficiency, viability, size and morphology were analyzed by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and exposure to environmental stress conditions and gastrointestinal simulation. The result revealed encapsulation efficiency values above 95 % for all formulations and survival rate higher than 6 log CFU/mL for most analyzed groups.

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Studies on climate change need to make projections based on predicted scenarios. One source of variability in these projections is the choice of general circulation models (GCMs). There is a lack of consensus on how to choose the GCMs.

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Chronic compartment syndrome (CCS) is a pressure increase within a non-expandable fibro-osseous space resulting from continuous and intense physical activity. Its symptoms usually improve with rest or reduced activity. It is a critical cause of lower limb pain in athletes and the second most common cause of effort-related leg pain.

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Measurable residual disease (MRD) testing in patients with acute myelogenous leukemia (AML) represents a heterogenous assessment process designed to quantify leukemia-specific biomarkers that are not ascertainable by routine pathologic evaluation. The most common tools used to assess MRD are multiparameter flow cytometry (MPFC), and polymerase chain reaction (PCR) based tools, including quantitative or digital droplet PCR (qPCR, ddPCR), or next-generation sequencing (NGS) technologies. Collectively, MRD assessments have become an important clinical tool in the management of patients with AML.

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In this study, participants ( = 144) first studied 40 word pairs, then restudied half of the word pairs and practiced retrieval with feedback on the other half. In separate sessions, they then completed cued-recall and fluid intelligence (gF) tests. Three main objectives were addressed.

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Article Synopsis
  • Interleukin-6 (IL-6) inhibitors are a new treatment for neuromyelitis optica spectrum disorder (NMOSD) and show promise in reducing relapse rates.
  • A systematic review and meta-analysis of four studies (involving 361 patients) found that IL-6 inhibitors significantly lowered the risk of relapses compared to placebo or traditional drugs.
  • However, there were no significant differences noted in overall disability, adverse events, serious adverse events, or infection rates, indicating a favorable safety profile for IL-6 inhibitors.*
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Measurable residual disease (MRD) in adults with acute myeloid leukemia (AML) in complete remission is an important prognostic marker, but detection methodology requires optimization. Persistence of mutated NPM1 or FLT3-ITD in the blood of adult patients with AML in first complete remission (CR1) prior to allogeneic hematopoietic cell transplant (alloHCT) associates with increased relapse and death after transplant. The prognostic implications of persistence of other common AML-associated mutations, such as IDH1, at this treatment landmark however remain incompletely defined.

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Routine genetic profiling of acute myeloid leukemia (AML) at initial diagnosis has allowed subgroup specific prognostication, drug development, and clinical management strategies. The optimal approach for treatment response assessment for AML subgroups has not yet however been determined. A nationwide cohort of 257 adult patients in first remission (CR1) from AML associated with an IDH2 mutation (IDH2m) undergoing allogeneic transplant during the period 2013-2019 in the United States had rates of relapse and survival three years after transplantation of 24% and 71%, respectively.

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Chimeric antigen receptor T-cell (CAR-T) therapies are effective in many hematologic malignancies; however, adverse events including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can affect a significant number of patients. Those who develop refractory CRS or ICANS have few treatment options. Siltuximab, a monoclonal antibody binding circulating interleukin-6, has been proposed to have clinical activity in both CRS and ICANS.

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Retrieving information from memory enhances long-term retention. In this manuscript, we describe the dual-memory framework, which makes interval-scale predictions of the magnitude of this retrieval practice effect. After outlining the framework, we use data from our laboratory-both at the group level and at the distribution level-to fit the equations from the dual-memory framework.

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Article Synopsis
  • Existing leishmaniasis treatments have limitations and side effects, prompting the exploration of new alternatives like the lectin DVL from Dioclea violacea seeds.
  • DVL showed significant leishmanicidal effects against Leishmania infantum in vitro, inducing reactive oxygen species and damaging the parasite's membrane, with an effective concentration of 49.37 μg/mL.
  • DVL enhanced the effectiveness of traditional drugs like amphotericin B and glucantime, reduced macrophage infection rates, and exhibited no toxicity in healthy cells, indicating its potential as a treatment for visceral leishmaniasis.
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Background: The L5-S1 interlaminar access described in 2006 by Ruetten et al. represented a paradigm shift and a new perspective on endoscopic spinal approaches. Since then, the spinal community has shown that both the traditional ipsilateral and novel contralateral interlaminar approaches to the L5-S1 foramen are good alternatives to transforaminal access.

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The present study aimed to evaluate the effectiveness of two doses of CoronaVac in preventing SARS-CoV-2 symptomatic disease with virological confirmation, as well as in the prevention of COVID-19 moderate and severe cases. A test-negative unmatched case-control design was used, in which cases were patients with suspected COVID-19 (presenting at least two of the following symptoms: fever, chills, sore throat, headache, cough, runny nose, olfactory or taste disorders) with virological confirmation, and controls were those whose SARS-CoV-2 test was negative. As for exposure, participants were classified as unvaccinated, or vaccinated with a complete schedule.

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Autologous chimeric antigen receptor-modified T-cell (CAR T) products have demonstrated un-precedent efficacy in treating many relapsed/refractory B-cell and plasma cell malignancies, leading to multiple commercial products now in routine clinical use. These positive responses to CAR T therapy have spurred biotech and big pharma companies to evaluate innovative production methods to increase patient access while maintaining adequate quality control and profitability. Autologous cellular therapies are, by definition, manufactured as single patient batches, and demand has soared for manufacturing facilities compliant with current Good Manufacturing Practice (cGMP) regulations.

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Sourdough production is a complex fermentation process. Natural sourdough fermentation without standardization causes great variability in microbial communities and derived products. Starter cultures have emerged as alternatives to natural fermentation processes, which could improve bakery quality and produce bioactive compounds.

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The Brazilian Amazon, a vital tropical region, faces escalating threats from human activities, agriculture, and climate change. This study aims to assess the relationship between forest fire occurrences, meteorological factors, and hospitalizations due to respiratory diseases in the Legal Amazon region from 2009 to 2019. Employing simultaneous equation models with official data, we examined the association between deforestation-induced fires and respiratory health issues.

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Background: The short-term complications from chimeric antigen receptor T-cell therapy (CART) are well characterized, but the long-term complications still need to be further investigated. Therefore, herein, we will review the currently available literature published on the late adverse events following CART.

Methods: We reviewed published data available from pivotal trials and real-world experiences with anti-CD19 CART (CART19) for adults with lymphoma.

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